In the title compound, [Fe(C5H5)(C33H25BrN3O)], the fused four-ring system, 11H-indeno-[1,2-b]quinoxaline is essentially planar, with a maximum deviation of 0.087 (3) Å from the least-squares plane of the attached benzene ring. The pyrrolidine rings adopt envelope conformation and make a dihedral angle of 51.76 (19)° with each other. The cyclopentadiene rings of the ferrocenyl moiety have an ec...

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug target because of its role in the development of Down syndrome and Alzheimer's disease. The selective DYRK1A inhibitor 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid (KuFal194), a large, flat and lipophilic molecule, suffers from poor water solubility, limiting its use as chemical probe in cellular ...

A new tricyclic alkaloid named portulacatone (1), i.e., 5,6-dihydro-8,9-dihydroxy-11H-pyrrolo[2,1b] [3]benzazepin-11-one, together with eight known compounds, methyl 4-hydroxyphenylacetate (2), phydroxybenzaldehyde (3), vanillin (4), protocatechualdehyde (5), p-hydroxybenzoic acid (6), iseluxine (7), oleracein E (8), and (þ)-(R)-feruloyl malate (9) were isolated from aerial parts of Portulaca o...

Developing the Wnt pathway inhibitors has been considered as a therapeutic approach for cancers and other Wnt-related diseases. Previously we found that the G-rich sequence of WNT1 promoter is capable of forming G-quadruplex structure and stabilizing agents for Wnt1-mediated signaling pathway. Using a established cell-based drug screen system that enabled the evaluation of WNT1 expression activ...

Intermediate wheatgrass (Thinopyrum intermedium (Host) Barkworth & D.R. Dewey) is being developed for use as a new perennial grain crop through breeding and agronomic research. However, progress has been hampered by lack of understanding environmental requirements flowering production. Therefore, we phenology model IWG adapted from the STICS soil-crop model. The was compliant with experimental ...