Shark cartilage is considered as a natural dietary supplement consisting of anti-angiogenic, immunostimulatory, and anti-inflammatory characteristics. Therefore, this study was designed to inspect the possibility that whitecheek shark (Carcharhinus dussumieri) cartilage proteins motivate expression of NKG2D, CXCR3, NKP46, and NKP44 receptors on natural killer cells and their activities against ...

Development of natural killer (NK) cells is thought to depend on interactions between NK progenitors and the bone marrow (BM) microenvironment; however, little is known about the molecular signals involved. Here we show that lymphotoxin (LT) provides an important signal for the development of both NK cells and NK/T cells. LTalpha-/- mice show marked reduction in splenic and BM NK and NK/T cell ...

Background Nasopharyngeal carcinoma, common in Southeast Asia, is mainly a non-keratinizing, squamous cell carcinoma (NK-NPC) and clinically heterogeneous. Methods Herein, we analyzed three human gene expression microarray datasets characterizing 81 NK-NPC tumors and 21 normal nasopharyngeal (NP) tissues to identify molecular subtypes of NK-NPC. In one of the datasets, QRT-PCR measurement of ex...

The study object is a prototype of composite bridge prestressed concrete beam with length 42.0 m for road desks perception impact from motor vehicles in the form A14, NK-120 and NK-180 loads.

The precise locations of neurokinin (NK)-1 and NK-2 receptors in human airways, and their role in airway inflammatory diseases, have not been carefully examined. To determine the distribution of NK-1 and NK-2 receptors in human central airways, and to determine whether their distribution was different in smokers, we examined surgical specimens from patients undergoing lung resection for limited...

Objectives: To assess the level of nutritional knowledge (NK) among male Kuwaiti college students and to correlate NK scores with different nutritional domains. Methods: A random sample of 378 students was asked to answer a questionnaire regarding socio-demographic and health-related factors and answer questions assessing their NK on different domains. Height and weight were measured. Results: ...

Background Natural killer (NK) cells are immune that can detect and eliminate tumor bridge innate to adaptive responses. Tumor specific activation of NK is thus an area active investigation in oncology, but date has relied on complex biologic modalities (e.g., antibodies, fusion proteins, or cell therapies), each which inherent disadvantages this application. Thus, alternative approaches warran...

PURPOSE Renal cell carcinoma harbors high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. This study focused on the natural killer (NK) cells infiltrating renal cell carcinoma. EXPERIMENTAL DESIGN Tumor-infiltrating lymphocytes (TIL) were isolated from renal cell carcinoma and analyzed for NK cell frequency and phenotype (n = 34). NK cells were enriched an...

Background: Alteration in peripheral blood lymphocytes (PBLs) is usually investigated to provide an evidence of the host immune responses to tumor antigens. The tumor infiltrating NK cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. Objective: To analyze peripheral blood and tumor associated Natural Killer (NK) cells in patients with breast ca...