BACKGROUND This study evaluated the application of a layered cell free poly (L-lactic acid) (PLLA) scaffold to regenerate an infraspinatus tendon defect in a rabbit model. We hypothesized that PLLA scaffold without cultivated cells would lead to regeneration of tissue with mechanical properties similar to reattached infraspinatus without tendon defects. METHODS Layered PLLA fabric with a smoo...

New development of biomaterial scaffolds remains a prominent issue for the regeneration of lost or fractured bone. Of these scaffolds, a number of bioactive polymers have been synthesized and fabricated for diverse biological roles. Although recent evidence has demonstrated that composite scaffolds such as HA/PLLA have improved properties when compared to either HA or PLLA alone, recent investi...

In the study reported here, a novel amphiphilic poly(aminoethyl ethylene phosphate)/poly(L-lactide) (PAEEP-PLLA) copolymer was synthesized by ring-opening polymerization reaction. The perfluoropentane-filled PAEEP-PLLA nanobubbles (NBs) were prepared using the O1/O2/W double-emulsion and solvent-evaporation method, with the copolymer as the shell and liquid perfluoropentane as the core of NBs. ...

In the current work, calcium silicate (CaSiO3) was blended with poly (L-lactic acid) (PLLA) to prepare PLLA/CaSiO3 composites, and crystallization process, melting process thermal decomposition behavior of composites were studied. The promoting effect CaSiO3 on PLLA proved by melt-crystallization, content a crucial factor PLLA. temperature significantly affected PLLA, double peaks degenerated i...

The aim of this study was to characterize the influence of functionalization of synthetic poly-(L-lactic acid) (PLLA) nanofibers on mechanical properties such as maximum load, elongation, and Young's modulus. Furthermore, the impact of osteoblast growth on the various nanofiber scaffolds stability was determined. Nanofiber matrices composed of PLLA, PLLA-collagen, or BMP-2-incorporated PLLA wer...

The morphologies and microstructures of neat 1,3:2,4-dibenzylidene-D-sorbitol (DBS) and DBS/ poly(L-lactic acid) (PLLA) samples have been investigated by polarizing optical microscopy (POM) and scanning electron microscopy (SEM). The morphology of neat DBS samples prepared from solution had unspecific structures, and no fibrils formed. In comparison, DBS molecules self-assembled into fibrils wi...

Current knowledge indicates that the molecular cross-talk between stem cells and biomaterials guides the stem cells’ fate within a tissue engineering system. In this work, we have explored the effects of the interaction between the poly(L-lactide) acid (PLLA) polymer film and human adult adipose stem cells (hASCs), focusing on the events correlating the materials’ surface characteristics and th...