The primary transforming functions of simian virus 40 large T antigen (SV40 LT) are conferred primarily through the binding and inactivation of p53 and the retinoblastoma family members. Normal p53 function requires an association with the CREB binding protein (CBP)/p300 coactivators, and a ternary complex containing SV40 LT, p53, and CBP/p300 has been identified previously. In this report, we ...

BACKGROUND Schizophrenia is associated with central (sagittal) midline reductions of the P300 cognitive event-related potential and topographic asymmetry of P300, with reduced left temporal voltage. This P300 asymmetry is, in turn, linked to tissue volume asymmetry in the posterior superior temporal gyrus. However, it is unknown whether P300 asymmetry is specific to schizophrenia and whether ce...

INTRODUCTION In patients with multiple sclerosis among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes. GOAL The aim of this study was to demonstrate that patients with multiple sclerosis have reduced amplitude and prolonged latency, longer than 300 ± 10 ms. METHODS The study included group of patients with multiple sclerosis and control group. After rev...

The P300-based brain-computer interface (P300 BCI) is currently a very popular topic in assistive technology development. However, only a few simple P300 BCI based-games have been designed so far. Here, we analyze the shortcomings of this BCI in gaming applications and show that solutions for overcoming them already exist, although these techniques are dispersed over several different games. Ad...

Because of the great sensitivity of P300 determined in prior research, the aim of this study was to investigate the mediate impact of some biological determinants of P300 on its relationship with extraversion. The sample consisted of 54 female psychology students, right-handers, in the age range of 19-23 years. The P300 was measured by visual oddball paradigm in two trials using EMG/EP device M...

The auditory P300 evoked potential was recorded in 36 subjects: left(LH) and right-handed (RH) schizophrenic males and LH and RH normal controls. LH and RH normals showed no asymmetry in P300 scalp topography. LH and RH schizophrenics, however, showed lateralized asymmetries in temporal scalp regions: left < right P300 voltage asymmetry in RH schizophrenics and left > right P300 voltage asymmet...

UNLABELLED The P300 results from focusing attention on rare stimuli in the midst of other frequent stimuli; it tests recent attention and memory, both of which depend on discriminating among verbal or nonverbal stimuli. AIM To compare the P300 with verbal and nonverbal stimuli in normal-hearing adults. MATERIAL AND METHOD A prospective study was made of 15 male subjects aged from 22 to 55, ...

The transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene. Animals nullizygous for p300 died between days 9 and 11.5 of gestation, exhibiting defects in neurulation, cell proliferation, and heart development. Cells derived from p300-deficient embry...

AIMS/INTRODUCTION Given the high prevalence of diabetes and burn injuries worldwide, it is essential to dissect the underlying mechanism of delayed burn wound healing in diabetes patients, especially the high glucose-induced hypoxia-inducible factor 1 (HIF-1)-mediated transcription defects. MATERIALS AND METHODS Human umbilical vein endothelial cells were cultured with low or high concentrati...

The discrepancy in the literature concerning the sensitivity of delayed P300 latency in dementia revolves around the variability of P300 latency in normal elderly. Previous studies, which have produced conflicting results, have utilized different P300 paradigms and different methods for measuring P300 latency. We demonstrate that the reported differences in the variability of P300 latency in no...