Gallic acid has been identified as an antioxidant component of the edible and medicinal plant Peltiphyllum peltatum. The present study examined its potential protective role against sodium fluoride (NaF)-induced oxidative stress in rat erythrocytes. Oxidative stress was induced by NaF administration through drinking water (1030.675 mg m(-3) for one week). Gallic acid at 10 mg kg(-1) and 20 mg k...

Podophyllum species are sources of (-)-podophyllotoxin, an aryltetralin lignan used for semi-synthesis of various powerful and extensively employed cancer-treating drugs. Its biosynthetic pathway, however, remains largely unknown, with the last unequivocally demonstrated intermediate being (-)-matairesinol. Herein, massively parallel sequencing of Podophyllum hexandrum and Podophyllum peltatum ...

INTRODUCTION Podophyllotoxin is the starting material for the semi-synthesis of the anti-cancer drugs etoposide, teniposide and etopophos. These compounds have been used for the treatment of lung and testicular cancers as well as certain leukemias. It is also the precursor to a new derivative CPH 82 that is being tested for rheumatoid arthritis in Europe, and it is the precursor to other deriva...

Podophyllum hexandrum Royle syn P. emodi Wall. ex Hook.f. & Thoms. is an endangered and valuable medicinal plant, distributed in the Himalayan zone at an altitudes ranging from 2000 to 4000 m above MSL. It is an herbaceous and rhizomatous perennial plant also found in few pockets of Indian cold desert (Ladakh and Lahaul-Spiti). Its rhizomes and roots contain about 8% of podophylloresin from whi...

A number of effective solution methods for the classical Generalised Assignment Problem (GAP) have been proposed during the last thirty years. Exact branch and bound approaches to solving GAP have been proposed by (Ross, Soland 1975, Martello, Toth 1990). More recently however heuristics have been utilised in order to reduce the size of the branch and bound tree by seeking good feasible solutio...

Human blood neutrophil granulocytes (neutrophils) treated with Podophyllum peltatum L.-derived compounds exhibited an enhanced oxidative response to subsequent challenge with bacterial formyl peptides. This priming effect was concerned with superoxide anion (O2-) release (respiratory burst). The phenomenon was observed with a potentized preparation containing, among other things, podophyllum ex...