Despite great public interest and desperate need, progress toward a viable human immunodeficiency virus (HIV) vaccine remains incredibly slow. Since Merck began its HIV vaccine research in 1985, the pharmaceutical company has yet to produce a vaccine capable of passing Phase II testing. Merck Laboratories President Peter S. Kim recently delivered a speech at Yale University that detailed his co...

H and C nuclear magnetic resonance (NMR) spectra were recorded at 400 MHz on a Bruker ARX-400 NMR spectrometer (Germany) with tetramethylsilane as internal standard. Column chromatography was performed using Merck (Germany) silica gel (230-400 mesh). Thin layer chromatography (TLC) was performed using Merck silica gel GF254, 0.25 mm thickness. For visualization, TLC plates were placed under aci...

Professor Karl August Folkers (Figure 1), a biochemist from the United States, was the head of one of the two research groups, one in England and one in the United States. In 1948, the two groups independently and simultaneously reported the isolation of vitamin B12 [1,2]. Most of Folkers’ work was carried out while working at the Merck Company (later Merck Sharp & Dohme) from 1934 to 1963. His...

18-Year Summary of Pregnancy Outcomes English Willis, MD; Ann Marko, BSN, RN; Mona Marin, MD; Sonja Rasmussen, MD; Stephanie R. Bialek, MD, MPH; Ann Redfield, MSN, RN; Maureen Mcgee, BSN, RN; Adrian Dana, MD; Clinical Safety and Risk Management, Merck Research Laboratories, Merck and Co., Inc., North Wales, PA; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA;...

D. C. BELL, A. J. BUTCHER, N. S. BERROW, K. M. PAGE, P. F. BRUST, A. NESTEROVA, K. A. STAUDERMAN, G. R. SEABROOK, B. NÜRNBERG, AND A. C. DOLPHIN Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom; Merck Research Laboratories, La Jolla, California 92307; Abteilung Pharmakologie und Toxikologie, Universität Ulm and Institut für Pharmakologie, Freie Universität,...