Camptothecin (CPT) derivatives have emerged as a promising group of chemotherapeutic agents. The FDA has approved the CPT derivatives topotecan and irinotecan for second line treatment of ovarian cancer and metastatic colorectal cancer, respectively. These and other CPT derivatives have become part of the multi-million dollar industry that is dedicated to finding better chemotherapeutic agents ...

BACKGROUND Combined physical therapy (CPT) is the treatment of choice for patients with lymphedema. Intensive stage CPT (I-CPT) results in a substantial reduction of the size of lymphedema, while the second stage CPT (M-CPT) maintains the achieved result for many years. AIM The article analyses the outcome M-CPT for 5 years in patients with lymphedema after mastectomy. METHODS Forty patient...

Carnitine palmitoyltransferase (CPT) I, which catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine facilitating its transport through the mitochondrial membranes, is inhibited by malonyl-CoA. By using the SequenceSpace algorithm program to identify amino acids that participate in malonyl-CoA inhibition in all carnitine acyltransferases, we found 5 conserved amino acids (Thr(314), Asn...

This talk contains a summary of our work on dynamical CPT invariance and spontaneous CPT violation in string theories, including the possibility that stringy CPT violation could occur at levels detectable in the next generation of experiments. In particular, we present here an estimate for values of parameters for CPT violation in the kaon system.

Hypothalamic fatty acid metabolism is involved in central nervous system controls of feeding and energy balance. Malonyl-CoA, an intermediate of fatty acid biosynthesis, is emerging as a significant player in these processes. Notably, hypothalamic malonyl-CoA has been implicated in leptin's feeding effect. Leptin treatment increases malonyl-CoA level in the hypothalamic arcuate nucleus (Arc), a...

A key regulatory point in the control of fatty acid (FA) oxidation is thought to be transport of FAs across the mitochondrial membrane by carnitine palmitoyltransferase I (CPT I). To investigate the role of CPT I in FA metabolism, we used in vivo electrotransfer (IVE) to locally overexpress CPT I in muscle of rodents. A vector expressing the human muscle isoform of CPT I was electrotransferred ...

7-Ethyl-10[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (CPT-11), a DNA topoisomerase I inhibitor, undergoes several metabolic pathways to generate conjugated and unconjugated derivatives that could be excreted from the body. The objective of this study was to determine the oxidative metabolites of CPT-11 recovered in human urine samples and to identify cytochrome P450 (CYP) involved...

Glutaredoxins (Grxs) are a class of small, heat-stable, acidic proteins which have been implied in various biological activities cells, including the defense against oxidative stress induced by biotic and abiotic factors. In this paper, effects RNAi targeting SeGrx1 on cytotoxicity insecticide susceptibility camptothecin (CPT) Spodoptera exigua were investigated. Results showed that CPT to cell...

7-Ethyl-10[4-(1-piperidino)-l-piperidino]carbonyloxycamptothecin (CPT-11; Irinotecan), a semisynthetic analogue of camptothecin (CPT) with broad preclinical antitumor activity, has demonstrated impressive activity in phase II trials in Japan in advanced small and non-small cell lung, colorectal, cervical, and ovarian carcinomas, as well as in refractory lymphomas and leukemias. In this phase I ...

Discovering unseen patterns from web clickstream is an upcoming research area. One of the meaningful approaches for making predictions using sequence prediction that typically improved compact tree (CPT+). However, to increase this method's effectiveness, combining it with at least other methods necessary. This work investigates such PageRank-based related as All-K-Markov, DG, Markov 1st, CPT, ...