This paper is concerned with numerical solutions of large scale Sylvester equations AX −XB = C, Lyapunov equations as a special case in particular included, with C having very small rank. For stable Lyapunov equations, Penzl (2000) and Li andWhite (2002) demonstrated that the so called Cholesky factored ADI method with decent shift parameters can be very effective. In this paper we present a ge...

Melanomas and other cancers that do not express argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sensitive to arginine depletion with pegylated arginine deiminase (ADI-PEG20). However, ADI resistance eventually develops in tumors because of AS upregulation. Although it has been shown that AS upregulation involves c-Myc, the underlying mechanisms remain ...

background the use of shielding tools and x-ray beam collimator has extensively been advocated as effective methods to reduce radiation exposure to patients underwent radiological procedures. the aim of this study was to address the use of these protection measures during infant chest radiography. material and methods 348digital and/or analogue infant chest radiographs were reviewed that perfor...

With the popularity of smart mobile devices, the amount of mobile applications (or simply called apps) has been increasing dramatically in recent years. However, due to low threshold to enter app industry, app developers vary significantly with respect to their expertise and reputation in the production of apps. Currently, there is no well-recognized objective and effective means to profile app...

Over 800 pesticides are currently approved for use in one or more EU countries. The maximum residue levels (MRL) for agricultural pesticides are derived from field trials conducted under good agricultural practice (GAP). The MRL is a legally enforceable limit related to GAP. The results from field trials would only be used to establish MRLs if the estimated intake of residues did not exceed the...

There are multiple lines of evidence that lactic acid bacteria (LAB) exert cancer-preventive effects. However, the underlying mechanisms are poorly understood. In the present study we found that the cytoplasmic fraction of Lactococcus lactis ssp. lactis American Type Culture Collection (ATCC) 7962 exerted the strongest antiproliferative effects (half-maximal inhibitory concentration (IC50) = 17...

Loss of argininosuccinate synthetase (ASS) expression in melanoma makes these tumor cells vulnerable to arginine deprivation. Pegylated arginine deiminase (ADI-PEG20) which degrades arginine to citrulline and ammonia has been used clinically and partial responses and stable disease have been noted with minimal toxicity. In order to improve the therapeutic efficacy of ADI-PEG20, we have combined...

A bioassay was developed to measure the minimum concentration of an antimicrobial drug that disrupts the colonization resistance mediated by model human intestinal microbiota against Salmonella invasion of Caco-2 intestinal cells. The bioassay was used to measure the minimum disruptive concentrations (MDCs) of drugs used in animal agriculture. The MDCs varied from 0.125 microg/ml for some broad...

The alternating direction implicit (ADI) method is an attractive option to use in avoiding the CourantFriedrichs-Lewy (CFL) condition that limits the size of the time step required by explicit finite-difference time-domain (FDTD) methods for stability. Implicit methods like Crank-Nicholson offer the same advantages as ADI methods but they do not rely on simple, one-dimensional, tridiagonal syst...

Streptococcus lactis metabolizes arginine by the arginine deiminase (ADI) pathway. Resting cells of S. lactis grown in the presence of galactose and arginine maintain a high intracellular ornithine pool in the absence of arginine and other exogenous energy sources. Addition of arginine results in a rapid release of ornithine concomitant with the uptake of arginine. Subsequent arginine metabolis...