Background: Adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. Despite immunostimulatory properties, the use of bacterial lipopolysaccharide (LPS) as an adjuvant has been hampered due to its toxicity and pyrogenicity. Brucella abortus LPS is less toxic and has no pyrogenic properties compared to LPS from other gram nega...

We describe performance enhancements that have been added to mkbTT, a modern completion tool combining multi-completion with the use of termination tools.

In 1979 Stockman introduced the SSS* minimax search algorithm that dominates Alpha-Beta in the number of leaf nodes expanded. Further investigation of the algorithm showed that it had three serious drawbacks, which prevented its use by practitioners: it is difficult to understand, it has large memory requirements, and it is slow. This paper presents an alternate formulation of SSS*, in which it...

Prior results show that most bounded query hierarchies cannot contain finite gaps. For example, it is known that PSAT (m+1)-tt = PSAT m-tt ) PSAT btt = PSAT m-tt and for all sets A FPA(m+1)-tt = FPAm-tt ) FPAbtt = FPAm-tt PA(m+1)-T = PAm-T ) PAbT = PAm-T FPA(m+1)-T = FPAm-T ) FPAbT = FPAm-T where PAm-tt is the set of languages computable by polynomial-time Turing machines that make m nonadaptiv...

We introduce pinta, a pipeline for reducing the upgraded Giant Metre-wave Radio Telescope (uGMRT) raw pulsar timing data, developed Indian Pulsar Timing Array experiment. provide detailed description of workflow and usage as well its computational performance RFI mitigation characteristics. also discuss novel independent determination relative time offsets between different back-end modes uGMRT...

Objective(s) The immunoadjuvant potential of cross-linked dextran microspheres (CDM) as absorption enhancer and Quillaja saponins (QS) as immunomodulator adjuvant was evaluated. Materials and Methods CDM loaded or tetanus-mixed toxoid (TT) or Quillaja saponin (QS) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum IgG and nasal lavage sIgA tite...