Profession influences healthcare workers' hand hygiene (HH) adherence. Greek nursing and medical students were surveyed to determine if there were cross-disciplinary differences in HH education, assessment, knowledge, beliefs and practices. Nursing students' HH knowledge was significantly higher than that of medical students. Nursing students reported significantly more positive HH practices an...

Glypican-3 (GPC3) is a heparan sulfate (HS) proteoglycan that is bound to the cell membrane through a glycosylphosphatidylinositol link. This glypican regulates embryonic growth by inhibiting the hedgehog (Hh) signaling pathway. GPC3 binds Hh and competes with Patched (Ptc), the Hh receptor, for Hh binding. The interaction of Hh with GPC3 triggers the endocytosis and degradation of the GPC3-Hh ...

Background: Health care-associated infections are a major patient safety issue worldwide. Hand hygiene (HH) campaigns have started all over the world to increase awareness and decrease HH barriers. The aim of this study was to assess healthcare professionals’ HH-knowledge, HH-barriers as well HH-environmental factors in general and especially in surgical and nonsurgical departments within a ter...

Hedgehog (Hh) signaling modulates tissue remodeling by controlling the fate of Hh-responsive cells. Healthy adult livers exhibit little Hh activity. However, cells involved in adult liver repair, including myofibroblasts and progenitors, are capable of producing and responding to Hh ligands. During adult liver injury, Hh ligand production increases and populations of Hh-responsive cells expand....

The Hedgehog (Hh) family of morphogenetic proteins has important instructional roles in metazoan development. Despite Hh being modified by Ct-cholesterol and Nt-palmitate adducts, Hh migrates far from its site of synthesis and programs cellular outcomes, depending on its local concentrations. We show that in the receiving cells of the Drosophila wing imaginal disc, lipid-unmodified Hh spreads a...

We present a kinematic study of the Herbig-Haro objects HH 202, 203 and 204 using Hα and [N II] Fabry-Perot velocity maps. For HH 202 we find new features that could belong to this HH object or that perhaps are associated with an outflow different from HH 202. Because of its high velocity (up to 100 km s) this outflow probably can be a HH flow not catalogued previously. Large internal motions a...

The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R antagonists as antiallergy drugs and to address the question of whether H(1)R ligands bind to hH(4)R. In an acute murine asthma model, the H(1)R antago...

BACKGROUND Many hand hygiene (HH) programs have been implemented across Sub-Saharan Africa (SSA); however, most of these have been in large, referral hospitals. Our objective was to assess the impact of HH programs aimed at improving compliance at a rural hospital, and to identify unique challenges to HH sustainability. METHODS Interventions to improve HH through providing handwashing station...