Antiphospholipid syndrome (APS) is an autoimmune disorder with increased risk for thrombosis and pregnancy losses. β2-glycoprotein I (β2GPI) is the major antigen for clinically relevant antibodies in APS. We engineered a molecule, A1-A1, which interferes with 2 prothrombotic mechanisms in APS: the binding of β2GPI to negatively charged cellular surfaces and ApoE receptor 2. We studied how A1-A1...

3,700,820 A 10/1972 Blasbalg et a1. 6,385,329 B1 5/2002 Sharma et a1. 6,580,694 B1 6/2003 Baker 6,584,125 B1 6/2003 Katto 6,728,678 B2 4/2004 Bhadkamkar et 211. 6,754,203 B2 6/2004 Wah et a1. 6,868,094 B1 3/2005 Bordonaro et a1. 6,956,871 B2 * 10/2005 Wang et a1. ................. .. 370/503 7,061,938 B2 6/2006 Hogeboom 7,260,220 B2 8/2007 Steenhof et a1. 7,295,578 B1 11/2007 Lyle et a1. 7,333,...

Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA(1) enzymes. Where their function is known, PLA(1)s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or r...

Background: There is an ongoing debate about the validity of the A1 criterion of PTSD. Whereas the DSM-5 has opted for a more stringent A1 criterion, the ICD-11 will leave it out as a key criterion. Objective: Here we investigated whether formal DSM-IV-TR traumatic (A1) and stressful (non-A1) events differ with regard to PTSD symptom profiles, and whether there is a gender difference in this re...

The cell plasma membrane contains specialized microdomains called lipid rafts which contain high amounts of sphingolipids and cholesterol. Lipid rafts are involved in a number of membrane protein functions. The urea transporter UT-A1, located in the kidney inner medullary collecting duct (IMCD), is important for urine concentrating ability. In this study, we investigated the possible role of li...