Rab coupling protein (RCP) is a Rab GTPase effector that functions in endosomal recycling. The RCP gene is frequently amplified in breast cancer, leading to increased cancer aggressiveness. Furthermore, RCP enhances the motility of ovarian cancer cells by coordinating the recycling of α5β1 integrin and EGF receptor to the leading edge of migrating cells. Here we report that RCP also influences ...

OBJECTIVE Measurement of cardiac perfusion via agents such as 99mTc-sestamibi (Cardiolite; DuPont-Merck Pharmaceutical Co., Inc.) is widely used in clinical nuclear medicine for the diagnosis of coronary artery disease. The monograph for 99mTc-sestamibi recommends at least 90% radiochemical purity (RCP) for clinical use. Various factors may influence the RCP of certain reagent kits. Some of the...

Introduction Historically considered to be a single cosmopolitan species, the so called Octopus vulgaris species complex (OVSC) is now recognized group of (at least) six cryptic species: O. americanus (in west Atlantic), northeast Atlantic and Mediterranean Sea), aff . region South Africa), tetricus (southeastern Oceania), sinensis (northwestern Pacific), djinda (western Australia). The potenti...

This study focused on the trends of rainfall variability and drought monitoring in northern region Pakistan (Gilgit-Baltistan). Climate Hazards Group Infrared Precipitation with Stations (CHIRPS) model data were used for period 1981 to 2020. The Standardized Index (SPI) was applied assess dry wet conditions during period. Mann–Kendall (MK) Spearman’s rho (SR) trend tests calculate drought. A co...

OBJECTIVE Regional cerebral perfusion (RCP) has been shown to provide cerebral circulatory support during Norwood procedure. In our institution, high-flow RCP (HFRCP) from the right innominate artery has been induced to keep sufficient cerebral and somatic oxygen delivery via collateral vessels. We studied the effectiveness of HFRCP to regional cerebral and somatic tissue oxygenation in Norwood...

With evidence suggesting that climate change is resulting in changes within the hydrologic cycle, ability to robustly model hydroclimatic response critical. This paper assesses how extreme runoff—1:2- and 1:30-year return period (RP) events—may at a regional level across UK by 2080s (2069–2098). Capturing uncertainty modelling chain, flow projections were extracted from EDgE (End-to-end Demonst...

Abstract Climate change is expected to have major negative effects on marine life across phylogenetic groups. Cephalopods, however, history characteristics that suggest they may benefit from certain climate scenarios. Of all cephalopods, squids reach the greatest biomasses; as a result, are of substantial importance for human and predator consumption. To test hypothesis beneficial commercial sq...

Objectives: Many interventional physiological assessments for retrograde cerebral perfusion (RCP) have been explored. However, the appropriate arterial gas management of carbon dioxide (CO2) remains controversial. The aim of this study is to determine whether alpha-stat or pH-stat could be used for effective brain protection under RCP in terms of cortical cerebral blood flow (CBF), cerebral met...

Interactive comment on “Stratospheric and tropospheric SSU/MSU temperature trends and compared to reanalyses and IPCC CMIP5 simulations in 1979–2005” by A. M. Powell Jr. et al. Anonymous Referee #1 Received and published: 13 February 2013 General comments: This paper shows that the selected CMIP5 models consistently capture such important climate features as the stratospheric cooling trend due ...