Purpose  Radiotherapy treatment planning of extended volume typically necessitates the utilization of multiple field isocenters and abutting dosimetrically matched fields in order to enable coverage beyond the field size limits. A common example includes total lymphoid irradiation (TLI) treatments, which are conventionally planned using dosimetric matching of the mantle, para-aortic/spleen, and...

Following a report of the efficacy of total lymphoid irradiation (TLI) in the treatment of chronic progressive multiple sclerosis a further randomised double-blind placebo-controlled study was undertaken with the intention of entering 56 patients. In the event it was possible to recruit only 27 patients in a 2.5 year period. Three patients received active treatment openly and 24 were randomised...

Nuklearmedizin 2/2011 © Schattauer 2011 W is se ns ch af tli ch es Pr og ra m m – Vo rt rä ge Schlussfolgerungen/Conclusions: Der unter Stimulationsbedingungen gemessene Tg-Wert ist, wenn er sechs Monate nach Therapie unter der Nachweisgrenze liegt, ein verlässlicher Prädiktor dafür, dass der Patient im weiteren Krankheitsverlauf tumorfrei bleibt. Wir schlagen vor, die Nachsorgefrequenz bei die...

Some twenty years ago, Bogen and Woodward challenged one of the fundamental assumptions of the received view, namely the theory-observation dichotomy and argued for the introduction of the further category of scientific phenomena. The latter, Bogen and Woodward stressed, are usually unobservable and inferred from what is indeed observable, namely scientific data. Crucially, Bogen and Woodward c...

BACKGROUND The extent of lung involvement visualized by high-resolution computed tomography (HRCT) is a predictor of decline in forced vital capacity (FVC) in scleroderma-interstitial lung disease. Our objective was to evaluate the performance of three different HRCT-defined staging systems in the Scleroderma Lung Study I (SLS I) over a 1-year period. METHODS We assessed two visual semiquanti...