it has been recognized that acute and chronic stress has an impact on the immune system. acute stress may have a stimulating effect on the immune system, while in the case of chronic stress specially depression, the immune system could be down-regulated. however, an association between depression and a higher number of circulating white blood cells with increased activity has been reported. ele...

Background: Cancer is a public health emergency. It has a high mortality rate despite numerous studies on pharmaceutical therapies. Chimeric antigen receptor-natural killer (CAR-NK) cells are promising immunotherapy that could be used to treat cancer, especially leukemia. However, the evidence is still unclear. Thus, this systematic review aims to summarize the evidence regarding the use of CAR...

Abstract Background: Cure rates for osteosarcoma (OS) have not improved in >30 years and no new effectivetherapies been identified metastatic disease. Natural killer (NK) cells become an attractive tool cancer immunotherapy. Efficay is by direct tumor targeting introducing a specific chimeric antigen receptor (CAR). Emerging knowledge suggests CD70 to be viable candidate as expression hi...

Introduction. Currently, more and attention is being paid to possible strategies for preventing the development of graft-versus-host disease (GVHD) reducing risk infections while maintaining antitumor effect — graft-versus-leukemia (GVL). In this context, study natural killer cells (NK-cells) seems be quite promising. Aim – analyze biological functional properties NK-cells after allo-HSCT, thei...

it has been demonstrated that natural killer (nk) cells play a role in regulation of autoimmunity. they play a protective role in several rodent disease models. in this study we aimed to compare the immunophenotypic features of nk cells in ankylosing spondylitis (as) with normal subjects with regard to cd56 and cd16 molecules. this study was carried out on 30 as patients and 33 normal volunteer...