Strategies for peroxisome proliferator-activated receptor (PPAR) activation or survivin inhibition have potential for cancer therapy. However, whether the combination of these two approaches can be developed as a rational regimen with enhanced efficiency in the inhibition of tumor cells remains to be determined. In this study, the combinatory effect of PPAR-γ agonist and survivin inhibition on ...

در این پژوهش تقویت باریکه لیزر تپی فمتوثانیه Ti:sapphire ­کننده بازتولیدی با آرایش هندسی Z براساس روش تپ چیرپ بررسی شده است. برای انتقال ورودی اولیه به داخل کاواک و استخراج از دو سلول پاکل استفاده زمان شکل‌گیری برحسب انرژی دمش مطالعه روند تحول مورد قرار گرفته مدت تولید بدون حضور 80 نانوثانیه فرایند 38 نرخ تکرار 10 هرتز طول موج مرکزی 800 نانومتر بیشینه 2 میلی‌ژول بعد 17 رفت برگشت 15 میلی ژول 532...

While the pro-tumorigenic function of heparanase is well taken, the role of its close homolog, heparanase 2 (Hpa2) in cancer is by far less investigated. Utilizing immunohistochemical analysis we found that Hpa2 is expressed by normal bladder transitional epithelium and its levels are decreased substantially in bladder cancer. Notably, tumors that retain high levels of Hpa2 were diagnosed as lo...

1. Six lactating white women, aged 24-36 years, received a single oral dose of 300 mg moclobemide, between 09.00 h and 11.00 h, 3 to 5 days after the delivery of a full term neonate. 2. Complete milk collections were obtained before, 3, 6, 9, 12 and 24 h after drug administration by means of a breast pump. Venous blood samples were drawn before, and 0.5, 1, 3, 4.5, 6, 9, 12, 24 h post-dosing. 3...

Rationale: Chemoresistance and subsequent recurrence of human urothelial bladder cancer (UBC) is partially driven by a subpopulation of tumor initiating cells, namely cancer stem cells (CSCs). However, the underlying molecular mechanism in chemotherapy-induced CSCs enrichment and following chemoresistance and recurrence remains largely unclear. Methods: Gemcitabine and cisplatin (GC) chemoresis...

OBJECTIVE Podophyllotoxin (PTOX), a natural compound in numerous plants, contains remarkable biological properties that include anti-tumor, anti-viral such as anti-human im- munodeficiency virus (HIV) activities. In order to avoid its adverse effects, various com- pounds have been derived from PTOX. 6-methoxy PTOX (MPTOX) is one of the natural PTOX derivatives with an extra methoxy group. MPTOX...

objective: podophyllotoxin (ptox), a natural compound in numerous plants, contains remarkable biological properties that include anti-tumor, anti-viral such as anti-human immunodeficiency virus (hiv) activities. in order to avoid its adverse effects, various compounds have been derived from ptox. 6-methoxy ptox (mptox) is one of the natural ptox derivatives with an extra methoxy group. mptox is...