نتایج جستجو برای: سلول های nb4

تعداد نتایج: 480512  

2003
Dorothy J. Park Peter T. Vuong Sven de Vos Dan Douer Phillip Koeffler

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations involving RAR and its fusion partners including PML and PLZF. Using oligonucleotide arrays, we examined changes in global gene expression mediated by the ectopic expression of either PML/RAR (retinoid-sensitive) or PLZF/RAR (retinoid-resistant) in U937 cells. Of over 5000 genes analyzed, 16 genes were commonly upre...

Journal: :Biochemical pharmacology 2002
Laetitia Devy Patrick Hollender Carine Munaut Alain Colige Roselyne Garnotel Jean Michel Foidart Agnès Noël Pierre Jeannesson

In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and NB4 cell lines, representative of acute myelogenous leukemia, their ability to express matrix metalloproteases (MMPs), tissue inhibitors of metalloproteases (TIMPs) and urokinase plasminogen acti...

Journal: :Blood 1993
C Labbaye J Zhang J L Casanova M Lanotte J Teng W H Miller Y E Cayre

Retinoic acid is known to induce differentiation of human myeloid leukemia cells in vitro. Recently, all-trans retinoic acid has been used to induce remissions in patients with acute promyelocytic leukemia, probably through differentiation of the leukemia cells. Myeloblastin (mbn) is a protease that has been identified in the human leukemia cell line HL-60. Downregulation of this protease can i...

2014
Li Zhang Qiu-Sheng Chen Peng-Peng Xu Ying Qian Ai-Hua Wang Dan Xiao Yan Zhao Yan Sheng Xiang-Qin Wen Wei-Li Zhao

BACKGROUND It has recently been reported that the extracts of green tea polyphenol have cancer preventive effects. In this study, we investigated the effect of the natural composition from green tea leaves Catechins on acute promyelocytic leukemia (APL). METHODS In vitro, APL cell lines NB4, retinoic acid-resistant NB4-R1 and NB4-R2 were treated with different concentrations of Catechins. Cel...

Journal: :Cancer research 2005
Yongkui Jing Nella Hellinger Lijuan Xia Anne Monks Edward A Sausville Arthur Zelent Samuel Waxman

All-trans retinoic acid (ATRA) induces clinical remission in patients with t(15;17) acute promyelocytic leukemia (APL) carrying leukemogenic promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) fusion protein by overcoming PML-RARalpha transcriptional repression and inducing myeloid differentiation. To identify more potent chemical differentiation inducers, a screening assay was d...

Journal: :Oncology reports 2007
She-Ning Qi Yuan-Xue Jing Gen-Xi Dong Yan Chen Akira Yoshida Takanori Ueda

DNA fragmentation into internucleosomal fragments is the best recognized biochemical event of apoptosis. Two major caspase pathways have been identified in the signal transduction leading to DNA fragmentation: the receptor pathway and the mitochondrial pathway. DNA fragmentation factor (DFF) has been identified as a major apoptotic endonuclease in the internucleosomal DNA fragmentation process....

2014
Li-min Xu Yue-juan Zheng Ying Wang Yang Yang Fan-fan Cao Bin Peng Xiong-fei Xu Hua-zhang An Ao-xiang Zheng Deng-hai Zhang Georges Uzan Yi-zhi Yu

All-trans retinoic acid (ATRA) is a revolutionary agent for acute promyelocytic leukemia (APL) treatment via differentiation induction. However, ATRA treatment also increases cytokine, chemokine, and adhesive molecule (mainly ICAM-1) expression, which can cause clinical complications, including a severe situation known as differentiation syndrome (DS) which can cause death. Therefore, it is of ...

Journal: :Blood 1999
M Fanelli S Minucci V Gelmetti C Nervi C Gambacorti-Passerini P G Pelicci

PML/RARalpha is the leukemogenetic protein of acute promyelocytic leukemia (APL). Treatment with retinoic acid (RA) induces degradation of PML/RARalpha, differentiation of leukaemic blasts, and disease remission. However, RA resistance arises during RA treatment of APL patients. To investigate the phenomenon of RA resistance in APL, we generated RA-resistant sublines from APL-derived NB4 cells....

Journal: :Blood 1997
R Morosetti D J Park A M Chumakov I Grillier M Shiohara A F Gombart T Nakamaki K Weinberg H P Koeffler

Human C/EBP epsilon is a newly cloned CCAAT/enhancer-binding transcription factor. Initial studies indicated it may be an important regulator of human myelopoiesis. To elucidate the range of expression of C/EBP epsilon, we used reverse transcription-polymerase chain reaction (RT-PCR) analysis and examined its expression in 28 hematopoietic and 14 nonhematopoietic cell lines, 16 fresh myeloid le...

ژورنال: طب جنوب 2004
جعفری, سید مجتبی, خواجه, خسرو, زندی, کیوان, ساجدی, رضا, سلیمانی, مسعود, فرسنگی, محمد حجت, قادری, عباس, نبی پور, ایرج,

خرگوش دریایی از نرمتنان دریایی است که بدلیل داشتن مواد باخواص بیولوژیک باوزن ملکولی کم ، توجه پژوهشگران را به خود معطوف داشته است . این نرم تن ماده ای بنفش رنگ جهت دفاع از خود آزاد می سازد که به نظر می رسد حاوی ترکیبات باپتانسیل ضد نئوپلاستیک باشد. برای خالص سازی پروتئین 60 کیلودالتونی موجود در ماده بنفش رنگ خرگوش دریایی Aplysia dactylomela خلیج فارس ، از تکنیک های تغلیظ پروتئین باسولفات آمون...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید