natural killer (nk) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. furthermore, they secrete interferon-γ (ifn-γ) and tumor necrosis factor (tnf) prompting adaptive immu-nity. nk cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. human nk cells use inhibi...

Background:  Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules.  These receptors could induce signals that determine NK cells ability to mediate cytotoxicity.  Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective:  To evaluate the influence of sHLA and two monoclonal an...

introduction: extranodal natural killer (nk)/t-cell lymphoma (nktcl) nasal type is a rare but well-known disease with poor prognosis. nktcl is more prevalent in asia and comprises about 7-10% of all non-hodgkin lymphoma cases in this region. the characteristic clinical pattern of nktcl is the destruction of the midline structures of the mid-face. case report: the present study examines a case o...

background: uterine natural killer (unk) cells are the most abundant leukocytes in pre-implantation endometrium and early pregnancy deciduas in humans and rodents. they are associated with structural changes in maternal spiral arteries but regulation of their re-cruitment and activation is incompletely understood. the major subpopulation of unk cells in humans expresses cd56, the neural cell ad...

background: multiple sclerosis (ms) and neuromyelitis optica (nmo) are inflammatory and demyelinating diseases of the central nervous system (cns). nk cells are supposed to play an important role in the pathophysiology of ms, but their role in the nmo remains unknown. the aim of this study was to compare the prevalence of different subpopulations of nk cells in the patients with ms and nmo and ...

Abstract Natural Killer (NK) cell-mediated cytotoxicity is a critical mechanism of the immune system to respond against harmful stimuli. The development emerging cell therapies, such as CAR-NK cells, requires deeper characterization cultured NK cells. Here we show phenotyping ex vivo and in vitro demonstrate how high quality reliable reagents from BioLegend ensure more depth cytotoxic analysis....

hematopoietic cord blood (cb) stem cell transplantation has more advantages to other cell sources because of lower graft versus host disease (gvhd). interleukin-15(il-15) is an immunoregulatory cytokine, known to enhance cytolytic function of cord natural killer (nk) cells. the aim of this study was to investigate the effect of il-15 on nk cytotoxicity simultaneously in different cell death sta...

behcet disease (bd) is a systemic inflammatory disease of the unknown etiology. there is however, some evidence to suggest that immunological abnormalities are important in its pathogenesis, furthermore several t-cell abnormalities which may be quite relevant to autoimmune origin of the disease have been described. we report here our study of t-cell subsets, b and nk cells in 68 patients with b...