Zinc is an important nutrient but can be lacking in some soil environments, influencing the physiology of soil-dwelling bacteria. Hence, we studied the global effect of zinc limitation on the transcriptome of the rhizosphere biocontrol strain Pseudomonas protegens Pf-5 (formerly Pseudomonas fluorescens). We observed that the expression of the putative zinc uptake regulator (Zur) gene was upregu...

Zinc is an essential micronutrient, required for a range of zinc-dependent enzymes and transcription factors. In mammalian cells, zinc serves as a second messenger molecule. However, a role for zinc in signaling has not yet been established in the fungal kingdom. Here, we used the intracellular zinc reporter, zinbo-5, which allowed visualization of zinc in the endoplasmic reticulum and other co...

In most bacteria, zinc depletion is sensed by Zur, whereas the surplus is sensed by different regulators to achieve zinc homeostasis. Here we present evidence that zinc-bound Zur not only represses genes for zinc acquisition but also induces the zitB gene encoding a zinc exporter in Streptomyces coelicolor, a model actinobacteria. Zinc-dependent gene regulation by Zur occurs in two phases. At s...

Zinc is an essential element in people’s diet. Too little zinc can cause health problems, but too much zinc is harmful. The U.S. Recommended Dietary Allowance (U.S. RDA) for zinc is 5 15 milligrams a day for humans. Not enough zinc in one’s diet can result in a loss of appetite, a decreased sense of taste and smell, slow wound healing and skin sores, or a damaged immune system. Young men who do...

Small-molecule fluorescent sensors are versatile agents for detecting mobile zinc in biology. Capitalizing on the abundance of validated mobile zinc probes, we devised a strategy for repurposing existing intensity-based sensors for quantitative applications. Using solid-phase peptide synthesis, we conjugated a zinc-sensitive Zinpyr-1 derivative and a zinc-insensitive 7-hydroxycoumarin derivativ...

Supplementation with zinc improves overall health, productivity and performance of production animals such as poultry, swine and dairy animals as measured by body weight increase, final body weight or feed/gain ratios. Reports on beneficial effects of zinc supplementation are fewer for companion animals. Lowe et al. (1994 a) reported more hair growth with higher zinc content in dogs upon supple...

BACKGROUND ZIP5 localizes to the baso-lateral membranes of intestinal enterocytes and pancreatic acinar cells and is internalized and degraded coordinately in these cell-types during periods of dietary zinc deficiency. These cell-types are thought to control zinc excretion from the body. The baso-lateral localization and zinc-regulation of ZIP5 in these cells are unique among the 14 members of ...

The aim of this study was to investigate the beneficial effect of vitamin E supplementation on zinc deficiency in experimental diabetes. Male alloxan-diabetic Wistar, albino rats of 10 weeks of age were divided into three groups. The first group received a diet containing 54 mg zinc/kg (adequate zinc group, AZ), the second group received a diet containing 1mg zinc/kg (zinc deficient group, ZD),...

objectives:crocin is one of constituents of saffron and has antioxidant property. zinc chloride is one of the common compounds of zinc with antioxidant activity. the present study was aimed to investigate separate and combined treatment effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in diabetic rats. materials and methods:diabetes was induced ...

results mean ± standard deviation (sd) of plasma zinc levels was determined as 0.78 ± 0.22 mg/l. also zinc level was 0.76 ± 0.19 mg/l and 0.80 ± 0.24 mg/l in thalassemic and non thalassemic patients, respectively. t-test analysis showed that there is no significant difference between these two groups regarding plasma zinc level (p = 0.235). conclusions it is concluded that zinc level of studied...