We consider gauge messenger models in which X and Y gauge bosons and gauginos are messengers of supersymmetry breaking. In simple gauge messenger models, all the soft parameters except μ and Bμ are calculated in terms of a single scale parameter MSUSY which is proportional to F/MGUT. Unique prediction on dark matter in gauge messenger models is discussed. (Based on hep-ph/0601036 and hep-ph/060...

Heparin (Hep) is a linear sulfated polysaccharide used in clinical treatment of tromboembolic diseases. In 2008, contaminated batches of Hep appeared in the pharmaceutical market. The contaminant was identified as an over sulfated form of chondroitin sulfate (oversulfated chondroitin sulfate, OSCS). Different analytical methods have been developed to identify and quantify OSCS and other impurit...

Amidst long-running debates within the field, High Energy Physics (HEP) has adopted a statistical methodology that primarily employs standard frequentist techniques such as significance testing and confidence interval estimation, but incorporates Bayesian methods for limited purposes. The recent discovery of the Higgs boson has drawn increased attention to the statistical methods employed withi...

BACKGROUND The Wnt/β-catenin signaling pathway plays a crucial role in embryonic development, tissue homeostasis, wound healing and malignant transformation in different organs including the liver. The consequences of continuous β-catenin signaling in hepatocytes remain elusive. RESULTS Livers of Ctnnb1CA hep mice were characterized by disturbed liver architecture, proliferating cholangiocyte...

OBJECTIVE To investigate the possible mechanisms of oxymatrine's role in anti laryngeal squamous cell carcinoma. METHODS We examined the effects of oxymatrine on the proliferation, cell cycle phase distribution, apoptosis, and the protein and mRNA expression levels of HPV16E7 gene in laryngeal carcinoma Hep-2 cells in vitro. The HPV16E7 siRNA inhibition was also done to confirm the effect of ...

Hepatocytes derived from human pluripotent stem cells (hPSC-HEP) have the potential to replace presently used hepatocyte sources applied in liver disease treatment and models of drug discovery and development. Established hepatocyte differentiation protocols are effective and generate hepatocytes, which recapitulate some key features of their in vivo counterparts. However, generating mature hPS...

A new spectrofluorometric method was developed for the determination of trace amounts of heparin (Hep). Using ciprofloxacin (CIP)-terbium (Tb3+) as a fluorescent probe, in a buffer solution of pH 7.20, Hep can remarkably enhance the fluorescence intensity of the CIP-Tb3+ complex at lambda = 545 nm; also, the enhanced fluorescence intensity the Tb3+ ion is proportional to the concentration of He...

Multidrug resistance (MDR) poses a serious impediment to the success of chemotherapy for laryngeal cancer. To identify microRNAs and mRNAs associated with MDR of human laryngeal cancer Hep-2 cells, we developed a multidrug-resistant human laryngeal cancer subline, designated Hep-2/v, by exposing Hep-2 cells to stepwise increasing concentrations of vincristine (0.02-0.96'µM). Microarray assays w...

OBJECTIVE To evaluate the frequency of clinical and laboratory manifestations in patients with primary antiphospholipid syndrome (PAPS) with positive antinuclear antibodies (ANA Hep-2+) compared to those in whom this antibody is negative (ANA Hep-2-). PATIENTS AND METHODS This is a transversal study with 58 patients (82.8% females) with PAPS. Demographic and clinical data, comorbidities, medi...

Homo sapiens is increasingly being studied within the evolutionary (adaptationist, selectionist) framework favoured by animal behaviour researchers. There are various labels for such work, including evolutionary psychology, human behavioural ecology and human sociobiology. Collectively, we call these areas 'human evolutionary psychology' (HEP) because their shared objective is an evolutionary u...