Novel acrylamide and methacryloyl carrying piperazine-dihydrofuran derivatives (3a-p) were designed obtained from radical cyclizations of unsaturated piperazine (1a-f) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)3. Obtained characterized spectroscopic methods. In vitro AChE inhibitory activites 3a-p evaluated against (Acetylcholinesterase) Ellman method test results showed that 3a, ...

هدف: با توجه به رشد روزافزون آموزش شیوه مجازی و ویژه در شرایط گسترش پاندمی کرونایروس، نقش اساسی مدیریت کلاسی ارتقا کیفیت باید مورد قرار گیرد این پژوهش هدف تدوین مدل رابطه علّی هدفمند کلاس وضعیت روان‌شناختی پیامدهای تحصیلی دانشجویان انجام شد. روش: روش بر حسب هدف، کاربردی ماهیت از نوع توصیفی - همبستگی بود. جامعه آماری مشتمل انواع مقاطع دانشگاه­ های دولتی پیام نور شهر تهران نمونه اساس جدول مورگان ب...

In the current study, a number of alkaloids including retamine, cytisine, and sparteine (quinolizidine-type), yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type) were tested in vitro for their inhibitory act...

A microplate assay and a thin-layer chromatography (TLC) "in situ" assay based on the Ellman assay was used to screen for acetylcholinesterase inhibitors from ethyl acetate and methanol extracts of Brazilian medicinal plants of families that, according to the literature, have traditional uses that might be connected with acetylcholinesterase inhibition. Eighteen species belonging to Convolvulac...

OBJECTIVE To assess the degree of poisoning in farmers using the erythrocyte acetylcholinesterase (AChE) test before and after the exposure to pesticides in townships in central Benin (Glazoué and Savè) and to identify the associated risk factors. METHODS Using a cross-sectional study design, we recruited 264 farm pesticide sprayers, who have been working for at least 5 years. They completed ...

A novel series of meta-substituted ethanediamide and 2-butenediamide derivatives were synthesized and tested for their ability to inhibit electric eel acetylcholinesterase (AChE) and equine serum butyrylcholinesterase (BuChE). The synthesized compounds were evaluated against ChE enzymes using the colorimetric method described by Ellman et al. (Biochem. Pharmacol., 7, 1961). It was revealed that...

A total of 30 chloroform and methanol extracts from the following endemic Soqotran plants Acridocarpus socotranus Olive, Boswellia socotranao Balf.fil, Boswellia elongata Balf. fil., Caralluma socotrana N. Br, Cephalocroton socotranus Balf.f, Croton socotranus Balf. fil.., Dendrosicycos socotrana Balf.f., Dorstenia gigas Schweinf. ex Balf. fil., Eureiandra balfourii Cogn. & Balf. fil., Kalancho...

Uma nova série de nove 3-fosfato-(4,4,4-trifluor-butil)-carbamatos de etila (compostos fosfatocarbamato), foram obtidos através da reação de (4,4,4-trifluor-3-hidroxibut-1-il)-etil carbamatos com oxicloreto de fósforo seguido de adição de álcoois. Os produtos foram caracterizados por espectroscopia de RMN de H, C, P e F, CG-EM e análise elementar. Todos os compostos sintetizados foram testados ...

The association of rheumatoid arthritis and Addison's disease in the same patient is very rare. In the English literature three papers reporting single cases have been found, and reference was made in two of these to three French articles dealing with the same subject (Perera and Ragan, 1950; Caughey and McCoy, 1951; Ellman and Cudkowicz, 1952). In these cases the onset ofrheumatoid arthritis p...

Cyclic tetrapeptide and depsipeptide natural products have proven useful as biological probes and drug candidates due to their potent activities as histone deacetylase (HDAC) inhibitors. Here, we present the syntheses of a class of cyclic tetrapeptide HDAC inhibitors, the azumamides, by a concise route in which the key step in preparation of the noncanonical disubstituted β-amino acid building ...