This paper compares the target displacement estimate from four current nonlinear static procedures—FEMA-356 CM, ASCE­ 41 CM, ATC-40 CSM, and FEMA-440 CSM—with the value derived from recorded motions of five strongly shaken reinforced concrete buildings.This comparison provides useful insight into two important questions: (1) how much does the target displacement vary among the four nonlinear st...

We collected samples monthly, from April to August 1998, to measure the abundance of autotrophic picoplankton in San Francisco Bay. Samples taken along a 160-km transect showed that picocyanobacteria (Synechococcus sp.) was a persistent component of the San Francisco Bay phytoplankton in all the estuarine habitats, from freshwater to seawater and during all months of the spring–summer transitio...

1) Nicotinic acetylcholine receptors in central nervous system are thought to be new targets for Alzheimer’s disease. However, the most involved nicotinic receptor subtype in Alzheimer’s disease is unclear. a4b2 receptor is the most widely spread subtype in brain, involving in several important aspects of cognitive and other functions. We constructed cell line by transfecting human amyloid prec...

Prabha Balaram1,*, Smriti M Krishna1, Susan James2, Vino. T. Cheriyan1, Sreelekha Therakathinal Thankappan1, Aleyamma Mathew3 Division of Cancer Research, Regional Cancer Centre, Medical College. P.O, Trivandrum 695 011, Kerala, India. Department of ENT, Medical College, Trivandrum 695-011, Kerala, India Department of Statistics, Regional Cancer Centre, Trivandrum, Kerala, India _______________...

Large conductance voltage- and Ca(2+)-activated potassium channels (BK channels) are important feedback regulators in excitable cells and are potently regulated by protein kinases. The present study reveals a dual role of protein kinase C (PKC) on BK channel regulation. Phosphorylation of S(695) by PKC, located between the two regulators of K(+) conductance (RCK1/2) domains, inhibits BK channel...

OBJECTIVE Prior research examining the effect of hepatitis C virus (HCV) on health-related quality of life (HRQoL) and healthcare costs is flawed because non-patient controls were not adequately comparable to HCV patients. The current study uses a propensity score matching methodology to address the following research question: is the presence of diagnosed hepatitis C (HCV) associated with poor...

The development of the coagulation and anticoagulation system in preterm infants was assessed, with special emphasis on extremely low birth weight (ELBW) infants and haemorrhagic or other complications after birth. Coagulation factors II (prothrombin), V (FV), VII (FVII) and X (FX) were analysed at birth and at a corrected age of six months. In addition, antithrombin (AT), protein C (PC) and pr...

Performance-based earthquake engineering organizes the explicit quantification of building seismic performance and risk, facilitating risk-informed design mitigation decisions. However, little work has been done to benchmark outcomes from these procedures with available empirical evidence past earthquakes. In this study, we end-to-end FEMA P-58 performance-based methodology against data Califor...