Thymineless death (TLD) in bacteria has been a focus of research for decades. Nevertheless, the advances in the last 5 years, with Escherichia coli as the model organism, have been outstanding. Independent research groups have presented compelling results that establish that the initiation of chromosome replication under thymine starvation is a key element in the scenario of TLD. Here we review...

OBJECTIVE Third Location Decompression (TLD) is an activity undertaken by UK Armed Forces (UK AF) personnel at the end of an operational deployment which aims to smooth the transition between operations and returning home. We assessed whether TLD impacted upon both mental health and postdeployment readjustment. METHOD Data collected during a large cohort study was examined to identify personn...

A laminated Ti-Al composite has been fabricated by hot compaction and hot rolling of alternate layers of commercial purity Ti and Al sheets with a thickness of 200 μm. The hot compaction temperature was 500 ̊C and in a following step the composite has been reduced 50% in thickness by hot rolling. The fully consolidated composite has been annealed at 300 ̊C and 500 ̊C for different length of time. ...

Polymer gel dosimetry undertaken on a multislice CT scanner provides an alternative method to conventional dosimetry measurements. Polymer gel dosimeters were used to measure CT radiation doses and compared to TLD and ionization chamber measurements in different diameter phantoms. CTDI was investigated for each of these phantoms for a range of mAs (100-400 mAs), tube voltage (100-135 kV) and no...

The early history of the esoteric phenomenon of thymineless death (TLD) is recounted, from the pioneering discovery by Seymour Cohen and Hazel Barner, through my graduate studies at Yale and postdoctoral research in Copenhagen. My principal contribution was the discovery that restricted synthesis of protein and RNA permits cultures of Escherichia coli to complete their DNA replication cycles wi...

The possibility to combine the track-etched CR-39 or Makrofol detectors with charcoal to increase the detector sensitivity was shown in the last years. Special requests are necessary in the case of a personal dosimeter when the detector must be active only during working activity. Regarding the combination of charcoal with TL detectors our preliminary investigations indicate that the TLD intens...