نتایج جستجو برای: حداکثر مدت زمان آواسازی mpt
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به منظور درک چرخه چرا و رفتار چرایی دام در شیب های مختلف مرتع، عادات و رفتار چرایی میش فشندی به عنوان دام غالب منطقه کردان البرز به مدت 4 سال مورد بررسی و مشاهده قرار گرفت. شاخص های مورد بررسی این تحقیق شامل مسافت روزانه طی شده توسط دام، مسیر دام در مرتع با توجه به شیب آن، سرعت دام (میانگین، حداکثر و حداقل)، همچنین مدت زمان استراحت و حرکت دام در روز بوده است. برای تعیین شاخص های ذکر شده از دستگ...
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Endogenous retroviruses are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Because four different classes of endogenous retroviruses, i.e., ecotropic, xenotropic, polytropic, or modified polytropic (mPT), are expressed in mice, we investigated the possibility that a particular class of endogenous retroviruses is associated with the development of murine SLE. We observed >...
OBJECTIVE Lung injury activates multiple pro-inflammatory pathways, including neutrophils, epithelial, and endothelial injury, and coagulation factors leading to acute respiratory distress syndrome (ARDS). Low-dose methylprednisolone therapy (MPT) improved oxygenation and ventilation in early pediatric ARDS without altering duration of mechanical ventilation or mortality. We evaluated the effec...
Korge, Paavo, Henry M. Honda, and James N. Weiss. Regulation of the mitochondrial permeability transition by matrix Ca and voltage during anoxia/reoxygenation. Am J Physiol Cell Physiol 280: C517–C526, 2001.—We studied the interplay between matrix Ca concentration ([Ca]) and mitochondrial membrane potential (Dc) in regulation of the mitochondrial permeability transition (MPT) during anoxia and ...
We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochondria. We devised a new model enabling incremental ROS accumulation in individual mitochondria in isolated cardiac myocytes via photoactivation of t...
Mitochondrial permeability transition (MPT) has been proposed to play a key role in cell death. Downstream MPT events include the release of apoptogenic factors that sets in motion the mitochondrial apoptosome leading to caspase activation. The current work examined the regulation of MPT by membrane fluidity modulated upon cholesterol enrichment. Mitochondria enriched in cholesterol displayed i...
We studied the interplay between matrix Ca(2+) concentration ([Ca(2+)]) and mitochondrial membrane potential (Deltapsi) in regulation of the mitochondrial permeability transition (MPT) during anoxia and reoxygenation. Without Ca(2+) loading, anoxia caused near-synchronous Deltapsi dissipation, mitochondrial Ca(2+) efflux, and matrix volume shrinkage when a critically low PO(2) was reached, whic...
Palmitoyl-CoA (Pal-CoA) lowered the respiratory control ratio (RCR), and induced mitochondrial membrane permeability transition (MPT) and cytochrome c (Cyt. c) release from isolated rat liver mitochondria. L-Carnitine suppressed the Pal-CoA-induced dysfunction, MPT, and Cyt. c release of isolated mitochondria. This suppression was inhibited by cephaloridine, an inhibitor of carnitine uptake int...
The initial analysis of the oral combination melphalan, prednisone, and thalidomide (MPT) in newly diagnosed patients with myeloma showed significantly higher response rate and longer progression-free survival (PFS) than did the standard melphalan and prednisone (MP) combination and suggested a survival advantage. In this updated analysis, efficacy and safety end points were updated. Patients w...
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