BACKGROUND The mouse strain sparse fur with abnormal skin and hair (spf(ash)) is a model for the human ornithine transcarbamylase (OTC) deficiency, an X-linked inherited urea cycle disorder. The spf(ash) mouse carries a single base-pair mutation in the OTC gene that leads to the production of OTC enzyme at 10% of the normal level. MATERIALS AND METHODS Recombinant adenoviruses carrying either...

Few-layer transition-metal dichalcogenide WSe2/MoSe2 nanosheets are fabricated by a liquid exfoliation technique using sodium deoxycholate bile salt as surfactant, and their nonlinear optical properties are investigated based on a balanced twin-detector measurement scheme. It is demonstrated that both types of nanosheets exhibit nonlinear saturable absorption properties at the wavelength of 1.5...

AIMS Tumour angiogenesis is essential for carcinogenesis and facilitates the process of tumour development and metastasis. Vascular endothelial growth factor (VEGF) is a well characterised angiogenetic factor and is known to play a crucial role in new vessel development. To gain further insight into the effects of microvessel density and VEGF expression in colon cancer, their relation with tumo...

A soft parameter function penalized normalized maximum correntropy criterion (SPF-NMCC) algorithm is proposed for sparse system identification. The proposed SPF-NMCC algorithm is derived on the basis of the normalized adaptive filter theory, the maximum correntropy criterion (MCC) algorithm and zero-attracting techniques. A soft parameter function is incorporated into the cost function of the t...

long exposure of uv radiation increases risk of skin diseases such as cancer and photoallergic reactions. uv-b (280-320 nm) radiation is mainly responsible for inducing skin problems. skin protection is a suitable method in the fight against ultraviolet radiation induced damage. various synthetic agents have been used as photo protective but because of their potential toxicity in humans, they h...

Specific Pathogen Free (SPF) embryonated eggs are used for the production of many veterinary and human vaccines. We have used High Throughput Sequencing to screen allantoic fluids and embryos for the presence of encapsidated viral genomes and viral transcripts, respectively. SPF eggs from two different producers were tested. We evidenced sequences corresponding to known endogenous retroviruses ...

The effect of infective, immunological, and irritative factors on the onset and development of silicosis after intratracheal inoculation with 50 mg of tridymite was investigated on 220 specific pathogen free (SPF) female Sprague-Dawley rats. Even after 12 months the rats, always kept in SPF conditions after intratracheal injection of the dust, showed mainly granulomas with little tendency to co...

abstract background and aims: vaccination of poultry has a major impact on the prevention and control of avian influenza viruses. nanobiotechnology techniques provide a new approach for improvement of influenza vaccine efficacy. in this study, efficacy of an inactivated nano-adjuvant vaccine developed based on an endemic h9n2 virus was evaluated in spf chickens. materials and methods: in each t...

To understand the perpetuation of inflammatory bowel disease (IBD), it is important to clarify whether the colitogenic CD4(+) T cells are self-limited effector or long-lived memory T cells. We here investigate the latency of colitogenic CD4(+) T cells in the remission stage of colitis under germfree (GF) conditions. We isolated splenic (SP) CD4(+) T cells from colitic CD4(+)CD45RB(high) T cell-...

The present study deals with the effects of alkaline and benzoyl chloride treatments sugar palm fibers (SPFs) on mechanical morphological properties SPF-reinforced poly(lactic acid) (PLA) composites. Seven different parameters SPFs were compared, which untreated, three solution concentrations 4%, 5%, 6% for treatment, 50 ml chloride-treated at soaking durations 10, 15, 20 min. Composites 30 wt....