Palau'amine has received a great deal of attention in the past two decades as an attractive synthetic target by virtue of its intriguing molecular architecture and significant immunosuppressive activity. Here we report the total synthesis of palau'amine characterized by the construction of an ABDE tetracyclic ring core including a trans-bicylo[3.3.0]octane skeleton at a middle stage of total sy...

We describe a self-assembling DNA-based nanosystem for interrogating molecular interactions. The nanosystem contains a rigid supporting dumbbell-shaped frame, a cylindrical central core, and a mobile ring that is coaxial with the core. Motion of the ring is influenced by several control elements whose force-generating capability is based on the transition of single-stranded DNA to double-strand...

Ring resonator optical switches using electro-optic materials have been proposed. The propagation loss of the waveguides and the resonance characteristics of ring resonators with different refractive indices are simulated. The operation voltage is estimated based on the results of the simulations and is found to be 0.70V in the case of the ring resonator switch with a K(Ta, Nb)O3 core and KH2PO...

The crystal structure of the title compound, C(15)H(11)FN(6)S, forms a three-dimensional network stabilized by π-π inter-actions between the imidazole core and the tetra-zole ring of the tetra-zolopyridine-unit; the centroid-centroid distance is 3.627 (1) Å. The crystal structure also displays bifurcated N-H⋯(N,N) hydrogen bonding and C-H⋯F inter-actions. The former involve the NH H atom of the...

Ubiquitin-mediated degradation of the cyclin-dependent kinase inhibitor p27 provides a powerful route for enforcing normal progression through the mammalian cell cycle. According to a current model, the ubiquitination of p27 during S-phase progression is mediated by SCF(Skp2) E3 ligase that captures Thr187-phosphorylated p27 by means of the F-box protein Skp2, which in turn couples the bound su...

Metropolitan area ring networks can be categorized into metro edge and metro core rings. The traffic characteristics of metro edge and metro core rings are quite different. While metro edge rings exhibit a strongly hubbed traffic pattern (hot spots), traffic demands in metro core rings are much more uniform. We examine the throughput-delay performance of a buffer insertion ring with destination...

A convergent synthesis of a des-B-ring bryostatin analogue is described. This analogue was found to undergo an unexpected ring expansion of the bryolactone core to generate the corresponding 21-membered macrocycle. The parent analogue and the ring-expanded product both displayed nanomolar binding affinity for PKC. Despite containing A-ring substitution identical to that of bryostatin 1 and disp...

Abstract We study accretion environments of active galactic nuclei when a supermassive black hole wanders in circumnuclear region and passes through an interstellar medium there. It is expected that Bondi–Hoyle–Lyttleton-type the matter takes place stream trapped by gravitational field appears from tail shock region. Since likely to have certain amount specific angular momentum, eventually form...

The photoionization of three N-heterocyclic carbenes (NHCs) has been studied in the valence and core regions using synchrotron radiation. We observed different variations in the relative band intensities with photon energy for the NHCs in the valence ionization region. This is due to the intra-ring interactions between the C=C bond, nitrogen and carbene lone pairs in the heterocyclic ring of NH...