نتایج جستجو برای: ترکیبات pah

تعداد نتایج: 30069  

2017
John Gerry Coghlan Nazzareno Galiè Joan Albert Barberà Adaani E Frost Hossein-Ardeschir Ghofrani Marius M Hoeper Masataka Kuwana Vallerie V McLaughlin Andrew J Peacock Gérald Simonneau Jean-Luc Vachiéry Christiana Blair Hunter Gillies Karen L Miller Julia H N Harris Jonathan Langley Lewis J Rubin

BACKGROUND Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), in particular systemic sclerosis (SSc), had an attenuated response compared with idiopathic PAH in most trials. Thus, there is uncertainty regarding the benefit of PAH-targeted therapy in some forms of CTD-PAH. OBJECTIVE To explore the safety and efficacy of initial combination therapy wit...

Journal: :Respiratory care 2010
Ariel M Modrykamien Ravindra Gudavalli Kevin McCarthy Joseph Parambil

BACKGROUND Pulmonary arterial hypertension (PAH) is frequently seen in patients with idiopathic pulmonary fibrosis (IPF). We sought to examine the performance of echocardiography, 6-min walk test (6MWT) distance, distance-saturation product (DSP), and pulse oximetry (SpO2) in detecting underlying PAH in IPF. METHODS 626 lung transplanted patients from February 1990 to December 2007 were consi...

2017
Kathleen Morrisroe Wendy Stevens Joanne Sahhar Candice Rabusa Mandana Nikpour Susanna Proudman Catherine Hill Sue Lester Peter Nash Gian Ngian Mandana Nikpour Susanna Proudman Maureen Rischmueller Janet Roddy Joanne Sahhar Wendy Stevens Gemma Strickland Vivek Thakkar Jenny Walker Jane Zochling

BACKGROUND Pulmonary arterial hypertension (PAH) is the leading cause of death in systemic sclerosis (SSc). Annual screening with echocardiogram (ECHO) is recommended. We present the methodological aspects of a PAH screening programme in a large Australian SSc cohort, the epidemiology of SSc-PAH in this cohort, and an evaluation of factors influencing physician adherence to PAH screening guidel...

Journal: :Clinical and experimental rheumatology 2008
S Chow J E Pope S Mehta

OBJECTIVE Pulmonary arterial hypertension (PAH) affects the quality of life (QoL) and the ability to perform the activities of daily living (ADLs) in patients with systemic sclerosis (SSc). We determined whether the Health Assessment Questionnaire-Disability Index (HAQ-DI), a self-assessment measure of function, correlates with a patient's PAH status in a population of SSc patients with PAH. ...

2013
Yvonne Dempsie Neil A. MacRitchie Kevin White Ian Morecroft Audrey F. Wright Margaret Nilsen Lynn Loughlin Kirsty M. Mair Margaret R. MacLean

AIMS Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expressio...

2014
Charles D. Burger Pamela K. Long Monarch R. Shah Michael D. McGoon Dave P. Miller Alain J. Romero Wade W. Benton Robert E. Safford

BACKGROUND Hospitalization is an important outcome in pulmonary arterial hypertension (PAH), shown previously to correlate with survival. Using the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL Registry), we sought to characterize first-time hospitalizations and their effect on subsequent hospitalization and survival in patients with newly diagnosed disease. METHODS ...

2016
Su-Jin Yoo Jae-Hyeong Park Yunseon Park Jae-Hwan Lee Byung-Joo Sun Jinhyun Kim In Seol Yoo Seung Cheol Shim Seong Wook Kang

BACKGROUND Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality among patients with systemic sclerosis (SSc). Early detection and prompt treatment of PAH associated with SSc (SSc-PAH) result in better prognosis. We conducted echocardiographic study to presume the prevalence of PAH in Korean adult SSc patients and to diagnose SSc-PAH in their early stages with right ...

Journal: :Angewandte Chemie 2021

Cationic BN-embedded polycyclic aromatic hydrocarbons (BN-PAH+s) were synthesized from a nitrogen-containing macrocycle via pyridine-directed tandem C?H borylation. Incorporating BN into PAH+ resulted in remarkable hypsochromic shift due to an increase the LUMO energy and symmetry changes of HOMO LUMO. Electrophilic substitution or anion exchange BN-PAH+ possessing tetrabromoborate as counter (...

2012
Kevin White Anne Katrine Johansen Margaret Nilsen Loredana Ciuclan Annabel Campbell Lynn Loughlin John D. McClure Kirsty M. Mair Margaret R. MacLean

Background—Pulmonary arterial hypertension (PAH) is a hyperproliferative vascular disorder observed predominantly in women. Estrogen is a potent mitogen in human pulmonary artery smooth muscle cells and contributes to PAH in vivo; however, the mechanisms attributed to this causation remain obscure. Curiously, heightened expression of the estrogenmetabolizing enzyme cytochrome P450 1B1 (CYP1B1) ...

Journal: :Heart & lung : the journal of critical care 2014
Santo Dellegrottaglie Ana García-Alvarez Pasquale Guarini Pasquale Perrone-Filardi Valentin Fuster Javier Sanz

OBJECTIVES To evaluate the occurrence of ventricular systolic dysfunction in human immunodeficiency virus (HIV)-related pulmonary arterial hypertension (PAH). BACKGROUND Patients with HIV-related PAH may develop ventricular systolic dysfunction both as a consequence of PAH progression or of the myocardial involvement from the HIV infection itself. METHODS Cardiac magnetic resonance imaging ...

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