We have used a two step procedure to identify peptides that bind strongly to the Rev-response element (RRE) of HIV. In the first step, RRE-binding peptides were screened from a combinatorial peptide library generated by "randomization" using a small subset of the 20 amino acids. In the second step, one such RRE-binding peptide, RSG-1, was "evolved" into an even stronger RRE-binding peptide usin...

We have written a 3D radiative transfer code that computes emerging spectra and intensity maps. We derive from radiative hydrodynamic (RHD) simulations of RSG stars carried out with COBOLD (Freytag et al. 2002) observables expected for red supergiant stars (RSG) especially for interferometric observations, with emphasis on small scale structures. We show that the convection-related surface stru...

The scope of this article is to discuss the dynamics of formatting customer expectations in financial services-under two models for assessing cumulative learning in customer expectations. The first model is a classical Bayesian one, the second model is an entirely new application of the Repetitive Stochastic Guesstimation (RSG) algorithm. The traditional assumption of postulating that empirical...

In the analysis looking for the signature X → HH → bb̄bb̄, where X is the Randall-Sundrum Graviton (RSG), this paper reveals the preliminary results and preparation work done to optimize the pT cut that we can make on the leading jet to optimize the limits that we can set on the cross section for the RSG particle. The limit setting is done using a frequentist approach and an asymptotics approxima...

An important problem is the removal of noise from input measurements and state estimates. Reverse engineering, or approximation, of black boxes within systems is also a highly relevant topic. Methods are given, including least squares methods and a Bayesian inverse approach, to perform these approximations. Real time methods are also considered, for example the Extended Kalman filter. A particu...

In this paper we consider the integrability of the mappings derived from the double discrete related sine-Gordon (∆∆RsG) equation, which we recently introduced in the paper Higher dimensional integrable mappings, under an appropriate periodicity condition.

Troglitazone (TRO), an effective thiazolidinedione antidiabetic agent, was reported to produce idiosyncratic hepatotoxic effects in some individuals. In contrast, rosiglitazone (RSG), in the same group of agents, has no significant toxic effects and now is widely used. In this study, human hepatoma (HepG2) cell lines were exposed to various doses of TRO as well as RSG (0, 25, 50, and 75 microM)...

Pulmonary hypertension (PH) is a progressive and often fatal disorder whose pathogenesis involves pulmonary artery smooth muscle cell (PASMC) proliferation. Although modern PH therapies have significantly improved survival, continued progress rests on the discovery of novel therapies and molecular targets. MicroRNA (miR)-21 has emerged as an important non-coding RNA that contributes to PH patho...