AIM To establish the frequency, associations and risk factors for age-related macular degeneration (AMD) in hospital population of South India. MATERIALS AND METHODS In this cross-sectional hospital based study, 3549 subjects (2090 men and 1459 women) above 45 years of age were screened randomly for AMD. Participants underwent ocular evaluation and were interviewed for lifestyle variables and...

PURPOSE Association between genetic variants in complement factor H (CFH), factor B (CFB), component 2 (C2), and in the ARMS2/HTRA1 region with age-related macular degeneration (AMD) comes mainly from studies of European ancestry and case-control studies of late-stage disease. We investigated associations of both early and late AMD with these variants in a population-based study of people aged ...

BACKGROUND Lipid metabolism and particularly high-density lipoprotein (HDL) may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with plasma HDL and other lipids, which may be confounded by the recently reported associations of AMD with HDL-related genes. We explored the association of A...

BACKGROUND The Age related Macular Degeneration (AMD) is a common cause of visual impairment and blindness worldwide in elderly. OBJECTIVE This study aimed to explore the demographic characteristics, pattern and risk factors for AMD at a tertiary referral eye centre in Nepal. METHODS This is a hospital-based prospective study, conducted at Tilganga Institute of Ophthalmology, Nepal from Sep...

Amiodarone (AMD) is a potent antiarrhythmic drug with high efficacy for treating atrial fibrillation and tachycardia. The pharmacologic profile of AMD is complex. AMD possesses biophysical characteristics of all of class I, II, III, and IV agents. Despite its adverse side effects, AMD remains the most commonly prescribed antiarrhythmic drug. AMD was described to prolong the QT interval and can ...

Amiodarone (AMD)-induced pulmonary toxicity (AIPT) is the most life-threatening side-effect of AMD treatment. N-Monodesethylamiodarone (DEA), an active metabolite of AMD, also exhibits cytotoxicity and tends to accumulate in the lung more intensively than AMD. In this study, we characterized the mechanism of DEA accumulation using A549 cells as a model of the alveolar epithelium. Typical ATP-de...

OBJECTIVE To investigate whether age-related macular degeneration (AMD) is associated with the development of myocardial infarction (MI) among elderly Americans. DESIGN Population-based cross-sectional and cohort study. PARTICIPANTS Five percent random sample of 2000 to 2003 Medicare enrollees. METHODS The cross-sectional study included the first 2-year (2000 and 2001) enrollees who were ...

Acid and metalliferous drainage (AMD) occurs when sulphidic minerals, such as arsenopyrite, chalcopyrite and pyrite, are exposed to oxygen and water. Climate, geology and mine site practices can have a significant impact on AMD composition. The elemental composition of the AMD can also affect the bacterial community. Our hypothesis was that in the dry season the AMD at two mine sites, Rum Jungl...

The chromatin structure of a diploid precursor B-cell line (REH), in >>/fro-stimulated normal B-lymphocytes, and reactive and malignant lymph node B-lymphocytes was studied by staining formaldehyde-fixed, permeabilized cells with the DNA-specific ftuorophore 7-aminoactinomycin D (7-AMD) and measuring single-cell fluorescence by flow cytometry. Resting peripheral blood Band T-lymphocytes (Go cel...

OBJECTIVE To investigate the incidence and progression of age-related macular degeneration (AMD) and associated risk factors. DESIGN Population-based, prospective, cohort study. PARTICIPANTS We included 2868 participants from the Age Gene/Environment Susceptibility-Reykjavik Study with retinal data at baseline and 5-year follow-up. METHODS Digital macular photographs were graded for prese...