Hypoxia-induced pulmonary hypertension, which is characterized by vascular remodeling of blood vessels, is an important complication in COPD. In this study, we found that the expression of miR-214 was differentially expressed by screening 13 candidate miRNAs in pulmonary artery smooth muscle cells (PASMCs). Additionally, using luciferase assay in PASMCs, we found that phosphatase-and-tensin hom...

A story on how an attempt to realize W. Heizenberg idea that the neutrino might be a Goldstone particle had led in its development to the discovery of supergravity action.

The deregulation of microRNAs (miRNAs) is involved in the development and progression of various types of human malignancy. Previously, it has been suggested that miR‑214 has an oncogenic role in nasopharyngeal carcinoma. However, the detailed molecular mechanisms remain to be elucidated. In the present study, reverse transcription‑quantitative polymerase chain reaction and western blot analysi...

The clinico-neuroradiological syndrome posterior cortical atrophy is the cardinal ‘visual dementia’ and most common atypical Alzheimer’s disease phenotype, offering insights into mechanisms underlying clinical heterogeneity, pathological propagation and basic visual phenomena (e.g. visual crowding). Given the extensive attention paid to patients’ (higher order) perceptual function, it is surpri...

Baran Sumer1, Jinming Gao2† †Author for correspondence 1Department of Otolaryngology, Head and Neck Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA Tel.: +1 214 648 3102; Fax: +1 214 648 2246; E-mail: baran.sumer@ utsouthwestern.edu 2Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5...

Du sequentiel au parallele: la recherche aborescente a la programmation quadra-tique en variables 0 et 1, 1987. Th ese d'Etat. 33] , A parallel branch and bound algorithm for the quadratic assignment problem, Discrete A GRASP FOR QAP 21 4. Concluding remarks. In this paper, we discussed aspects of a GRASP implementation for solving the QAP. The algorithm was tested on a broad range of test prob...

Objective: To assess the influence of pharmacists’ opinions on their dispensing medicines with a «medical prescription only» label without requiring a doctor’s prescription. Methods: We performed a cross-sectional study of 166 community pharmacies in northwest Spain. The opinions of pharmacists on the following were collected as independent variables through personal interview: a) physicians’ p...