The regulation of AMPA-type glutamate receptor (AMPAR) membrane trafficking is a key mechanism by which neurons regulate synaptic strength and plasticity. AMPAR trafficking is modulated through a combination of receptor phosphorylation, ubiquitination, endocytosis, and recycling, yet the factors that mediate these processes are just beginning to be uncovered. Here we identify the ubiquitin-conj...

میون‌­ها به دلیل سطح مقطع کوچک برای انجام واکنش، متداول‌­ترین تابش فضایی قابل آشکارسازی در زمین هستند. همانند سایر ذراتی که از طریق برخورد ذرات پرانرژی تولید می‌­شوند، ناپایدار و دارای طیف توزیع طول عمر این مقاله، انرژی میون با استفاده سیستم طیف‌­سنجی دیجیتال اندازه‌­گیری شده است. روش ارایه همه ماژول­ه‌ای الکترونیک هسته‌­ای آنالوگ حذف فرایند شکل­ دهی سیگنال‌­ها ثبت آن­ها صورت نرم­‌افزاری اندازه...

Neurons are sensitive to low oxygen (hypoxia) and employ a conserved pathway to combat its effects. Here, we show that p38 MAP Kinase (MAPK) modulates this hypoxia response pathway in C. elegans. Mutants lacking p38 MAPK components pmk-1 or sek-1 resemble mutants lacking the hypoxia response component and prolyl hydroxylase egl-9, with impaired subcellular localization of Mint orthologue LIN-10...

Wireless ad hoc routing has been extensively studied and many clever schemes have been proposed over the last several years. One class of ad hoc routing is geographic routing where each intermediate node independently selects the next hop using the given location information of destination. Geographic routing, which eliminates the overhead of route request packet flooding, is scalable and suita...

Language-centered software engineering requires language technology that (i) handles the full class of context-free grammars, and (ii) accepts grammars that contain syntactic information only. The syntax definition formalism SDF combined with GLR-parser generation offers such technology. We propose to make SDF and GLR-parsing available for use with various programming languages. We have done so...

For sequential jumps detection, isolation and estimation in discrete-time stochastic linear systems, Willsky and Jones (1976) have developed the Generalized Likelihood Ratio (GLR) test. For the treatment of sequential jumps, the jump-free Kalman filter is updated on-line after each detection of one jump by a direct state estimate and covariance incrementation using the informations produced by ...

We describe and experimentally evaluate a system, FeasPar, that learns parsing spontaneous speech. To train and run FeasPar (Feature Structure Parser), only limited handmodeled knowledge is required. The FeasPar architecture consists of neural networks and a search. The networks spilt the incoming sentence into chunks, which are labeled with feature values and chunk relations. Then, the search ...