BACKGROUND Renal dysfunction was reported to be closely associated with clinical outcomes in patients with chronic heart failure (CHF). Renal tubulointerstitial damage has been shown to be an important factor in the development of renal dysfunction as well as glomerular damage. However, the impact of renal tubular damage on clinical outcomes in patients with CHF remains to be determined. METH...

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β2m: β2-Microglobulin; β2m-free HC: β2m-free Heavy Chain; CTL: CD8+ Cytotoxic T Lymphocytes; DSA: Donor Specific Antibodies; HC: Heavy Chain Polypeptide; HLA: Human Leukocyte Antigens; HLA-I: Human Leukocyte Antigen Class I; HLA-II: Human Leukocyte Antigen Class II; IFNγ: Interferon-γ; kDa: kilodalton; MHC: Major Histocompatibility Complex; MMP: Matrix Metalloproteinase; rHLA: Recombinant HLA; ...

INTRODUCTION Cardio-renal syndromes are characterized by the impairment of cardiac and renal functions. Plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL), and plasma B-type natriuretic peptide (BNP) are markers of acute kidney injury (AKI) and heart failure (HF), respectively. METHODS GFR (99mTc-DTPA), plasma BNP, and plasma and urinary concentrations of NGAL were measured ...

Background: A subgroup of T and B cells express the extracellular enzyme cluster differentiation (CD73), which hydrolyzes adenosine monophosphate to adenosine. This work aimed evaluate CD73 expression its correlation with other disease characteristics in leukemia chronic lymphocytic type (CLL) patients. Methods: cross-sectional research was done on 30 CLL cases diagnosed by laboratory investiga...

BACKGROUND AND OBJECTIVES Because little is known about long-term treatment-related nephrotoxicity, the aim was to determine risk factors for renal impairment long after childhood cancer treatment. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Data from 763 adult childhood cancer survivors (414 men) were obtained during regular visits at the late-effects clinic between 2003 and 2009. Median f...

BACKGROUND Bone metastasis is the most lethal form of several cancers. The β2-microglobulin (β2-M)/hemochromatosis (HFE) complex plays an important role in cancer development and bone metastasis. We demonstrated previously that overexpression of β2-M in prostate, breast, lung and renal cancer leads to increased bone metastasis in mouse models. Therefore, we hypothesized that β2-M is a rational ...

OBJECTIVE To determine the prognostic significance of beta2 microglobulin (β2-m) concentrations in patients with hemophagocytic lymphohistiocytosis (HLH), a rare disorder caused by pathologic activation of the immune system. PATIENTS AND METHODS The study population consisted of 74 patients diagnosed with HLH and 35 healthy controls. Serum β2-m levels were measured using a latex agglutination...

The environment is that part of living and non-living nature surrounds organisms directly or indirectly affects their existence, development reproduction.The increase toxic substances in the human body beyond permissible norm leads to a progressive such chronic diseases as: respiratory cardiovascular systems, genetic congenital malformations, poisoning, malignant tumors, allergies, blood diseas...