Ghrelin is a growth hormone-releasing peptide that also displays orexigenic activity. Since serine-3 acylation with octanoylate (octanoylation) is essential for the orexigenic activity of ghrelin, suppression of octanoylation could lead to amelioration or prevention of obesity. To enable the exploration of inhibitors of octanoylated ghrelin production, we developed a cell-based assay system usi...

The present study assessed the possibility for the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) as an antiaging compound for the skin by assaying senescence-associated β-galactosidase (SA-β-Gal), a biomarker of senescence and cell viability. The nitric oxide (NO) donor sodium nitroprusside (SNP) increased in SA-β-Gal-positive cells in cultured h...

Rat hepatoma (Morris 7777) cells modified with either oleic or linoleic acid exhibited greater susceptibility to normal spleen cell-mediated lysis in a 16-hr 51Cr release assay. At effector:target cell ratios of 300:1, the specific lysis of fatty acid-enriched target cells (cultured for 2 days in fatty acid-supplemented medium) by the normal rat spleen cells was 60% higher than the untreated ta...

objective: antioxidants are considered as the main factors in the inhibition of unwanted oxidation reactions. materials and methods: in this research the antioxidant potential of the fresh fruits of 4 cultivars (a to d) of malus domestica (m. domestica) cultivated in the kashan, qamsar area was evaluated. the antioxidant activity of the samples were evaluated using two complementary antioxidant...

ABSTRACT: The object of this study is to extract the oil from millets and evaluate the chemical properties of the extracted oil. Commercial millet oil was obtained by cold solvent extraction adopting soxhlet procedure. Quantitative and qualitative tests concerned with the non-saponifiable matter, fatty acid composition, phosphorus content representing total phospholipids, refractive index, pero...

Objectives: The objective of this research was to investigate the chemical composition and antibacterial activities of the fatty acids and essential oil from various parts of Ligularia persica Boiss (L. persica) growing wild in north of Iran. Materials and Methods: Essential oils were extracted by using Clevenger-type apparatus. Antibacterial activity was tested on two Gram-positive and two Gra...

BACKGROUND Diabetes therapy that not only lowers glucose levels but also lengthens life spans is required. We previously demonstrated that DPP-4 inhibition ameliorated β cell apoptosis and adipose tissue inflammation in β cell-specific glucokinase haploinsufficient mice fed a diet containing a combination of sucrose and linoleic acid (SL). METHODS In this study, we investigated the effects of...

iran annually exports considerable quantities of nuts such as almonds, hazelnuts, pista-chios and walnuts. the fatty acid profile of these nut oils as an index of their quality was determined using gas chromatography. results indicated that oleic acid (c18:1) was the major fatty acid in almonds (75.37%), hazelnuts (76.21%) and pistachios (60.49%) fol-lowed by linoleic acid (c18:2), whereas in w...