diagnosis of cancer of the lung and colon. The fact that a patient had a previous lung tumor is not an indication for routine periodic bronchoscopy unless clinical, roentgenologic, cytologic (sputum), and other findings warrant it. We are unaware of scientific evidence to support the statement that “¿ endobronchial tumors migrate down the path ofleast resistance If the tumor is found early an...

Homomeric AMPA receptors (AMPARs) composed solely of GluA1 subunits are permeable to Ca , whereas heteromeric receptors containing GluR2 are not. PhosphorylationofGluA1bycAMP-dependentprotein kinase (PKA) in hippocampal neurons stabilizes Ca -permeable AMPARs in extrasynaptic membranes, where they can move into synapses during long-term potentiation (LTP). Dephosphorylation of GluA1 by calcineu...

We describe a conceptually simple technique for estimating the contributions of individual degradation mechanisms to the wearout of RF GaN HEMT. This is important because most “physics of failure” studies on such devices report several distinct mechanisms that operate simultaneously. As a result, the overall degradation rate for a given GaN HEMT technology does not have a well-defined thermal a...

Background: With the Ebola epidemic raging out of control in West Africa, there has been a flurry of research into the Ebola virus, resulting in the generation of much genomic data. Methods: In response to the clear need for tools that integrate multiple strands of research around molecular sequences, we have created the University of California Santa Cruz (UCSC) Ebola Genome Browser, an adapta...

June 30, 2002 · Emergence Roger Strand Strand R. Complexity, Ideology, and Governance. Emergence: Complexity and Organization. 2002 Jun 30 [last modified: 2016 Nov 21]. Edition 1. doi: 10.emerg/10.17357.e39b775425bcb7efc31ddadca5742f9e. On the one hand, modern societies have achieved an impressive level of organization and welfare with their great number of highly differentiated institutions an...

Calcium entry into nerve terminals is generally considered one of the most reliable aspects of synaptic transmission, although the probability of transmitter release at excitatory synapses often is low. Because high concentrations of calcium are required for release, free calcium must be high at active zones. However, the small size of most active zones has made it difficult to assess calcium l...

Macrophages are terminally differentiated cells of the mononuclear phagocyte system that also encompasses dendritic cells, circulating blood monocytes, and committed myeloid progenitor cells in the bone marrow. Both macrophages and their monocytic precursors can change their functional state in response to microenvironmental cues exhibiting a marked heterogeneity. However, there are still uncer...

The Swiss mathematician Armand Borel died August 11, 2003, in Princeton from a rapidly evolving cancer. Few foreign mathematicians had as many connections with France. He was a student of Leray, he took part in the Cartan seminar, and he published more than twenty papers in collaboration with our colleagues Lichnerowicz and Tits, as well as with me. He was a member of Bourbaki for more than twe...

The Swiss mathematician Armand Borel died August 11, 2003, in Princeton from a rapidly evolving cancer. Few foreign mathematicians had as many connections with France. He was a student of Leray, he took part in the Cartan seminar, and he published more than twenty papers in collaboration with our colleagues Lichnerowicz and Tits, as well as with me. He was a member of Bourbaki for more than twe...