Selective placement of an aliphatic â-alanine (â) residue paired side-by-side with either a pyrrole (Py) or imidazole (Im) aromatic amino acid is found to compensate for sequence composition effects for recognition of the minor groove of DNA by hairpin pyrrole-imidazole polyamides. A series of polyamides were prepared which contain pyrrole and imidazole aromatic amino acids, as well as γ-aminob...

the Nuclear Regulatory Com mission (NRC) by the Society ofNuclear Medicine and the American College ofNuclear Physiciansover four years ago is finally getting some response. The reaction from the peti tion's original author, however, has been less than favorable. Carol S. Marcus, PhD, MD, Director of Nuclear Medicine and Outpatient Clinic atHarbor-UCLAMedicalCenter and the principalauthorof the...

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic i -I la-ruv protooncogene containing 8-hydroxyguanine in the second po sition of codon 12 (GGC) in NIH3T3 cells. Transaction of this gene significantly increased the number of transformed foci. The c-Ha-r<w gene present in these foci was analyzed by the polymeras...

Mechanisms for resistance were studied in three classic type, human small cell lung cancer cell lines, (.!(,,, (.I.(',„,and <;i.<',.i, that were established from one patient during clinical follow-up. Clinically the tumor changed from sensitive (<;!,(,,) to completely resistant to (chemo)therapy ((il.(.',,,) during this period. The stain with JSB-1 anti body, detecting the M, 170,000 multidru...

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

Background—Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract caused by an abnormal and uncontrolled immune response to one or more normally occurring gut constituents. Aim—Given the eVects of transforming growth factor â1 (TGF-â1) on both the immune system and extracellular matrix, we postulated that alterations in TGF-â signalling in intestinal epithelial...

Using a structural VAR with block exogeneity, diagonality and identifying restrictions, this paper analyzes: first, the macroeconomic linkages among the oil price, U.S. output, interest rate, money supply, general price level and exchange rate and second, the relationships of the macroeconomic variables with the price indices of ten international nonfuel commodity groups. By assuming the block ...

We optimized the modulation of drug resistance by the irreversible augmentation of cytotoxicity of coincubating vinblastine (VNB) with VP16 and the reversible increase in cytotoxicity of coincubation of verapamil (VPL) with VNB and VP-16. VPL was administered as a loading dose (i.v.) (0.15 mg/kg) and then administered as a constant infusion (0.005 mg/kg) over 6 days. 24 h after verapamil, VNB 2...