نتایج جستجو برای: zygomycetes
تعداد نتایج: 349 فیلتر نتایج به سال:
β-Glucosidases (β-D-glucoside glucohydrolases) play important role in nature, including the degradation of cellulosic biomass by fungi and bacteria, breakdown of glycolipids in mammalian lysosomes, and the cleavage of glycosylated flavonoids in plants. These enzymes have broad substrate specificity, and are used in a range of biotechnological processes. The most intensively studied area of thei...
The respiratory tract is the primary mode of entry for the Zygomycetes. Pulmonary infections usually occur in the immunocompromised patient and resemble those caused by the aspergillus spp. Risk factors include hematologic problems, ketoacidosis, long- term immunosuppressive therapy, and underlying lung disease. Needle aspirates or biopsy specimens provide the best yield for diagnosis. Tissue s...
Combinations of antimicrobial agents were tested against 35 strains of zygomycetes. The interaction between amphotericin B and rifampin was synergistic or additive. Flucytosine alone was inactive and, upon combination with amphotericin B, synergy was not achieved. The combination of amphotericin B with terbinafine was synergistic for 20% of strains, and the interaction between terbinafine and v...
Three isolates of zygomycetes belonging to two different genera (Rhizopus oryzae and Absidia corymbifera) were used to produce a systemic infection in neutropenic mice. On days -2 and -1 and at 2 h prior to infection, the mice received either posaconazole (POS) at doses ranging from 20 to 80 mg/kg of body weight/day or amphotericin B (AMB) at 1 mg/kg/day. Antifungal drug efficacy was assessed b...
The rising incidence of invasive fungal infections due to the expanding population of immunocompromised hosts and the increasing prevalence of fungal resistance has led to the need for novel antifungal agents. Posaconazole, a new member of the triazole class has demonstrated in vitro activity against a broad spectrum of fungi and clinical activity against various fungal pathogens, including Asp...
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