The coordination number of the catalytic zinc ion in alcohol dehydrogenase has been studied by integrated ab initio quantum-chemical and molecular mechanics geometry optimisations involving the whole enzyme. A four-coordinate active-site zinc ion is 100-200 kJ/mol more stable than a five-coordinate one, depending on the ligands. The only stable binding site for a fifth ligand at the zinc ion is...

The metabolic syndrome is a group of factors associated with an increased risk of atherosclerosis and diabetes. Diabetes mellitus (DM) is classified into 2 major types—type 1 DM and type 2 DM—characterized by chronic hyperglycemia resulting from defects in insulin secretion and insulin action, respectively. Several synthetic pharmaceuticals have been developed and clinically used for treating D...

A series of four related phenol derivatives, with 2,2'-dipicolylamine substituents at the ortho positions, were prepared and their Zn2+ coordination complexes studied by spectroscopic methods. X-ray crystal diffraction analysis of a dinuclear zinc complex with two bridging acetate anions showed a ternary structure with highly charged interior and lipophilic exterior, which helps explain why thi...

In this study, we focused on microfluidic electrochemical analysis of zinc complexes (Zn(phen)(his)Cl2, Zn(his)Cl2) and ZnS quantum dots (QDs) using printed electrodes. This method was chosen due to the simple (easy to use) instrumentation and variable setting of flows. Reduction signals of zinc under the strictly defined and controlled conditions (pH, temperature, flow rate, accumulation time ...

Zinc can be inserted into the carbahemiporphyrazines by use of the organometallic reagent diethylzinc; in the case of benziphthalocyanine, concomitant alkylation of an alpha-carbon position and metalation occurs.

Two murine homologs of the Drosophila Kriippel gene, a member of the gap class of developmental control genes that encode a protein with zinc fingers, were mapped to mouse chromosomes 8 and 11 by using somatic cell hybrids and an interspecific backcross. Surprisingly, both genes were closely linked to two previously mapped, Krtippelrelated zinc finger protein genes, suggesting that they are par...

X-Ray, Zinc, Schiff Bases, Electrochemical Synthesis The electrochemical synthesis and physico-chemical properties of neutral zinc(II) complexes of bidentate Schiff bases derived from salicylaldehydes are presented together with the X-ray structure of bis[N-(4-methylphenyl)salicylaldiminato]zinc(II). The crystal is monoclinic, a = 21.877(3), b = 8.801(2), c = 12.027(5) Ä , ß = 96.55(3)°, space ...

TDMQ chelators have been designed as drug-candidates for the regulation of copper homeostasis and reduction oxidative stress in brain Alzheimer's patients. To achieve suitable biological properties high Cu(II) selectivity a zinc-rich medium, ligands must meet critical coordination chemistry requirements related to structures CuII-TDMQ complexes. The correlation between X-ray diffraction Cu- Zn-...

We describe the synthesis and characterization of two new zinc (II) and cadmium (II) complexes of the tetradentate dissymmetric Schiff base ligand 2-((E)-(2-(2-(pyridine-2-yl)ethylthio)ethylimino)methyl)-4-bromophenol (PytBrsalH), prepared from 1-(2-pyridyl)-3-thia-5-aminopentane (pyta) and 5-bromosalicylaldehyde. The complexes were synthesized by treating an ethanolic solution of the ligand wi...