xrcc2

Robert Fred Henry Walter Claudia Vollbrecht Robert Werner Thomas Mairinger Jan Schmeller Elena Flom Jeremias Wohlschlaeger Nikolaos Barbetakis Dimitrios Paliouras Fotios Chatzinikolaou Vasilis Adamidis Kosmas Tsakiridis Paul Zarogoulidis Georgia Trakada Daniel Christian Christoph Kurt Werner Schmid Fabian Dominik Mairinger

BACKGROUND Malignant pleural mesothelioma (MPM) is a rare, predominantly asbestos-related and biologically highly aggressive tumour leading to a dismal prognosis. Multimodality therapy consisting of platinum-based chemotherapy is the treatment of choice. The reasons for the rather poor efficacy of platinum compounds remain largely unknown. MATERIAL AND METHODS For this exploratory mRNA study,...

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Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model

2016

Kwon Joong Yong Diane E. Milenic Kwamena E. Baidoo Martin W. Brechbiel

In pre-clinical studies, combination therapy with gemcitabine and targeted radioimmunotherapy (RIT) using 212Pb-trastuzumab showed tremendous therapeutic potential in the LS-174T tumor xenograft model of disseminated intraperitoneal disease. To better understand the underlying molecular basis for the observed cell killing efficacy, gene expression profiling was performed after a 24 h exposure t...

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