Epithelial and haematologic tumours often show the overexpression of serine/threonine kinase AURKA. Recently, AURKA was shown to localise at mitochondria, where it regulates mitochondrial dynamics ATP production. Here we define molecular mechanisms in regulating turnover by mitophagy. triggers degradation Inner Mitochondrial Membrane/matrix proteins interacting with core components autophagy pa...

Angiogenesis is a complex multistep process that comprises proliferation, migration, and anastomosis of endothelial cells, followed by stabilization of the newly formed vessel through the attachment of support cells. This process is imbalanced in a large number of disorders, including cardiovascular disease, diabetes and cancer. Evidence indicates that xanthohumol (XN), a prenylated chalcone pr...

Abstract Bioactive compounds extracted from plant are of great value for those enterprises interested in the use natural products; tissue culture techniques guarantee a reliable and constant biomass production. Hop ( Humulus lupulus L.), with its wealth bioactive compounds, may represent an invaluable resource. The present study focused on characterization vitro -derived leaves roots two hop ty...