Epilepsy is a chronic neurological disorder characterized by recurrent seizures. However, approximately one-third of epilepsy patients still suffer from uncontrolled seizures. Effective treatments for epilepsy are yet to be developed. N (6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside (B2) is a N(6)-substitued adenosine analog. Here we describe an investigation of the effects and mechanisms of...

We focus on the second virial coefficient B2 of fluids with molecules interacting through hard-sphere potentials plus very short-ranged attractions, namely, with a range of attraction smaller than half hard-sphere diameter. This kind of interactions is found in colloidal or protein suspensions, while the interest in B2 stems from the relation between this quantity and some other properties of t...

A direct pathway for the fragmentation of peptide b3 fragment ions to b2 ions has, until now, not been identified. Experimental evidence for the formation of a b3 anhydride structure and isomerization to an extended macrocycle is demonstrated here by comparison of the completely different fragmentation patterns of the b3 ions generated from protonated VGEIG and its methyl ester. In particular, ...

PURPOSE The ephrin receptors (Eph) are found in a wide range of cancers and correlate with metastasis. In this study, we characterized the role of Eph-B2 receptor in the interaction of Waldenstrom's macroglobulinemia (WM) cells with the bone marrow microenvironment. EXPERIMENTAL DESIGN We screened the activity of different receptor tyrosine kinases in WM patients and found that Eph-B2 was ove...

UNLABELLED BACKGROUND Liver fluke can infect cattle and sheep, and is also emerging as a human pathogen in developing countries. Cathepsin B (Cat B2) is a major cysteine protease secreted by the juvenile flukes. To enhance the immune responses of Cat B2, the cDNA sequence was fused with four different DNA vaccine vectors. The induced cellular and antibody responses were compared in vaccinate...

Recently Andrei Teleman considered instanton moduli spaces over negative definite four-manifolds X with b2(X) ≥ 1. If b2(X) is divisble by four and b1(X) = 1 a gauge-theoretic invariant can be defined; it is a count of flat connections modulo the gauge group. Our main result shows that if such a moduli space is non-empty and the manifold admits a connected sum decomposition X ∼= X1#X2 then both...

Given three mutually tangent circles with bends (or the reciprocal of the radius) a, b and c respectively, an important quantity associated with the triple is the value 〈a, b, c〉 := ab + ac + bc. In this note we show in the case when a central circle with bend b0 is “surrounded” by four circles, i.e., a flower with four petals, with bends b1, b2, b3, b4 that either p 〈b0, b1, b2〉 + p 〈b0, b3, b...

In order to find out the relationship between the cerebrovascular acetazolamide reactivity and platelet function in asymptomatic cerebral thrombosis, 10 cases of asymptomatic cerebral infarction and 10 age-matched control subjects were studied. The cerebrovascular acetazolamide reactivity was measured using xenon computed tomography method. As markers of platelet function, the plasma concentrat...

To determine if amplification of the C-erb-B2 proto-oncogene could be correlated with prognosis in carcinoid tumours, 49 pulmonary carcinoid tumours (26 typical, 23 atypical) were examined using a polyclonal antibody to the C-terminal peptide of the C-erb-B2 protein sequence. No C-erb-B2 gene product could be shown: the demonstration of C-erb-B2 does not seem to help, therefore, in determining ...