OBJECTIVE To evaluate the associations between (1) antidrug antibody (ADAb) and therapeutic response, (2) ADAb and serum drug trough levels and (3) serum drug levels and therapeutic responses in rheumatoid arthritis (RA) patients receiving adalimumab or etanercept. Secondarily, we aim (1) to evaluate the concordance between radioimmunoassay and bridging ELISA for ADAb assessment and to evaluate...

One of the most promising methods of interacting with small portable computing devices, such as personal digital assistants, is the use of handwriting. In order to make this communication method more natural, we proposed to visually observe the writing process on ordinary paper and to automatically recover the pen trajectory from numerical tablet sequences. On the basis of this work we develope...

The abstract must not contain references, as it may be used without the main article. It is acceptable, although not common, to identify work by author, abbreviation or RFC number. (For example, "Our algorithm is based upon the work by Smith and Wesson.") Avoid use of "in this paper" in the abstract. What other paper would you be talking about here? Avoid general motivation in the abstract. You...

Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. Treatment options include biologic therapies; however, a proportion of patients lose response to biologics, partly due to the formation of anti-drug antibodies (ADAbs). Concomitant immunosuppressive agents reduce the development of ADAbs. This review article aims to assess the immunogenicity...

BACKGROUND Uganda is one of the 57 countries with a critical shortage of health workers. The aim of this study was to determine how the human resources and health service crisis was covered in Ugandan newspapers and, in particular, how the newspapers attributed accountability for problems in the health services. METHODS We collected all articles related to health workers and health services f...

BACKGROUND This study investigated the nature of newspaper reporting about online health information in the UK and US. Internet users frequently search for health information online, although the accuracy of the information retrieved varies greatly and can be misleading. Newspapers have the potential to influence public health behaviours, but information has been lacking in relation to how news...

Millions of pages of historical newspapers have been digitized but in most cases access to these are supported by only basic search services. We are exploring interactive services for these collections which would be useful for supporting access, including automatic categorization of articles. Such categorization is difficult because of the uneven quality of the OCR text, but there are many clu...