We have recently shown that mechanical forces, experimentally imposed or physiologically generated, transiently disrupt or wound the plasma membranes of epithelial cells of the gut and that cultured endothelial cells similarly wounded mechanically at their plasma membranes release a potent basic fibroblast growth factor-like molecule. Here we show that mechanical forces generated by experimenta...

The search for significantly overrepresented and co-occurring transcription factor binding sites in the promoter regions of the most differentially expressed genes in microarray data sets could be a powerful approach for finding key regulators of complex biological processes. To test this concept, two previously published independent data sets on wounded human epidermis were re-analyzed. The pr...

Wound healing succeeds tissue destruction. We hypothesized that antibodies might bind to wounded tissues, which would facilitate the engulfment of damaged tissues by macrophages. We detected the autoantibodies in sera of different ages of mice, which bind to wounded tissues. We detected IgG1 binding to wounded tissues by using FITClabeled anti-IgG1 in C57BL/6 mice. These bands were highest in 4...

The house was " sold out"?-packed from floor to ceiling. And small wonder since, apart from any sentimental reasons, that marvellous man, Mr. Alan Adair, had provided a full afternoon's entertainment of talent, humour and rollicking jollity. Many of the capable artists were greeted like old friends, which, indeed, they were, often having given their services on previous occasions to hearten up ...

Deborah Grassman’s presentation, “Wounded Warriors: Their Last Battle” has dramatically and almost singlehandedly increased awareness of Veterans and their unique end-of-life issues in both VA and the community. Not only has Ms Grassman given this presentation to dozens of audiences across the country, a DVD has been widely distributed to VA and community healthcare providers as an effective te...

Blood volume tests made on a number of soldiers recovering from hemorrhage have shown that in many instances dilution of the blood occurs very slowly. The principal reasons for this seem to be (a) an initial lack of reserve fluid of the tissues, and (b) the absence of any subsequent attempt by the body to make up this fluid deficiency. By putting such patients on a large fluid intake by mouth a...

“Of all the surgical operations which are performed in man for the preservation of life by the physician, I have always judged to be the foremost that by which man is recalled from a quick death to a sudden repossession of life, a feat which raises to the level of Aesculapius; the operation is the opening of the asperia arteria [trachea], by which patients, from a condition of almost suffocatin...

For me and my fellow citizens, the war started on May 2, 1991, with the massacre of Croatian guardsmen in Borovo Selo. Until August 25, the wounded were brought to the hospital every day, indicating that fights were going on close to Vukovar. We never expected such destruction and terror but realized that we had to prepare for a total war. The Crisis Management Council of the hospital was estab...

Three known physiological responses to exogenous cytokinins were measured in wounded and nonwounded cotyledons from cucumber (Cucumis sativus L. cv Marketer) seedlings grown in darkness. Enhanced cell division, chlorophyll formation, and cotyledon expansion were detected in wounded cotyledons. The data suggest that wounding enhances endogenous cytokinin activity.