The sequence-specific recognition of the minor groove of DNA by pyrrole-imidazole polyamides has been extended to 9-13 base pairs (bp). Four polyamides, ImPyPy-Py-PyPyPy-Dp, ImPyPy-G-PyPyPy-Dp, ImPyPyâ-PyPyPy-Dp, and ImPyPy-γ-PyPyPy-Dp (Im ) N-methylimidazole, Py ) N-methylpyrrole, Dp ) N,Ndimethylaminopropylamide, G ) glycine, â ) â-alanine, and γ ) γ-aminobutyric acid), were synthesized and c...

7 [1] Tropical rainforests are known to exhibit low intrasea8 sonal precipitation variability compared with oceanic areas 9 with similar mean precipitation in observations and models. 10 In the present study, the potential role of transpiration for 11 this difference in precipitation variability is investigated 12 using the National Center for Atmospheric Research 13 (NCAR) atmospheric general ...

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one mineral density measurements are useful for predicting the risk of fracture in an individual, for assessing the effect of a disease or drug on bone mass, and for monitoring the effect of therapy of osteoporosis. For the hip and spine, measurements made at the affected site discriminate better between fragility fractures and nonfracture cases than do measure ments made on other parts of the ...

Some thoughts are externally singular: there is an object which the thought is about. Some thoughts which are not externally singular are internally singular: although there is no object the thought is about, it recruits resources of a kind appropriate to external singularity. An illustration: Jack wants a sloop (I am using ‘‘thought’’ broadly, so that wanting is a species of thinking). The des...

Aims—To assess immunohistochemically whether the neural cell adhesion molecule L1, which is a member of the immunoglobulin superfamily and has been shown recently to be a stimulating factor for glioma migration, is expressed in glioma tissues, and to investigate factors that can regulate this expression. Methods—Twenty seven glioma tissue specimens including 13 glioblastomas, seven anaplastic a...

â increase in wastage of soil resources in watershed is a persistent challenge that with increase in population and pressure on natural sources and unstable plantation on gradient farms and soils cause production reduces on farms, and also decrease in daily ratio of farms to population can cause more pressure on lands and natural resources.lavarefin watershed placed in 60 km from bandarabass in...

â â â  reports indicate that the mahabad dam has been silting up more than it was expected. this research has been tried to study the causes and the agents of these changes. a duration of two years periods (that is from october 1986 to october 1987 and october 1991 to october 1992) was taken up to compare and then to determine the role of the sedimentation on these changes. results show that th...

We used flow cytometry to measure the expression of human mela noma antigens on cell suspensions dissociated from metastatic masses. The objective was to study the heterogeneity between tumor samples from different patients and between different tumors excised from a single patient. Fifty-three métastasesexcised from 34 melanoma patients »ere analyzed with a panel of nine murine monoclonal an...

In an attempt to better understand breast tumors sensitivity or resis tance to anticancer drugs, the main drug-metabolizing enzyme systems were evaluated in both breast tumors and their corresponding peritumoral tissues in 12 patients. The following enzymes were assayed by Western blot: cytochromes P-4SO (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4); glutathione .S'-transferases (GST-a, -u, and -TI); and ...