The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...

We greatly appreciate the interest of Li and Yu (1) in our article (2) that evaluated the use of PCR assays for diagnosis of prosthetic joint infection (PJI). In their letter, Li and Yu raised some thoughtful comments regarding the selection of the included studies and performed an updated meta-analysis. They indicated that two similar studies (3, 4) by Kobayashi et al. were performed during th...

AIMS/INTRODUCTION Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) is a novel potential marker of inflammatory responses. The objective was to evaluate the association between NLR and carotid artery intima-media thickness (cIMT) in type 2 diabetes. MATERIALS AND METHODS We carried out a case-control study involving 320 patients with type 2 diabetes, and 250 age-, sex- ...

BACKGROUND We sought to characterize the pharmacodynamic profile of the more intensive vancomycin dosing regimens currently used in response to the recent vancomycin guidelines. METHODS A series of Monte Carlo simulations was performed for vancomycin regimens ranging from .5 g intravenous (IV) Q12H to 2 g IV Q12H. The probability of achieving an AUC/MIC ratio ≥ 400 for each dosing regimen was...

The purpose of this study was to investigate the comparative diagnostic strength of C-reactive protein (CRP) values in synovial fluid and serum in patients with presumed periprosthetic joint infection. We collected 44 synovial fluid samples and 24 serum samples from 43 patients. Patients were judged to be uninfected or infected based on standardized criteria. Synovial and serum samples were obt...

Anisocoria during anesthesia is very rare, but may indicate life-threatening neurologic injuries and create tremendous condition. A 23-year-old male patient was anesthetized with fentanyl and propofol. Thirty minutes after inducing anesthesia, unilateral mydriasis was detected. The duration of surgery was shortened for prompt evaluation of the pupils. At the end of the operation neither vision ...

In this paper, a markovian queue with two types of servers and buffer space is considered. The resequencing constraint is imposed according to which the customers leave the system in the same order in which they entered it. For finite buffer queue, the steady state queue size distribution has been obtained.?