The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bond...

BACKGROUND Bullous pemphigoid is the most common autoimmune blistering skin disease of the elderly. Because elderly people have low tolerance for standard regimens of oral corticosteroids, we studied whether highly potent topical corticosteroids could decrease mortality while controlling disease. METHODS A total of 341 patients with bullous pemphigoid were enrolled in a randomized, multicente...

Escherichia coli is the predominant cause of urinary tract infections, and is gaining prominence in medical practice due to increasing resistance to widely used antimicrobials including some specified in the world Health Organization’s Model List of Essential Drugs. A cross-sectional analytical research design was conducted to determine the serotypes and antimicrobial resistance phenotypes of E...

This report proposes a standard method to characterize variability and sensitivity of functional neuroimaging experiments. Most functional neuroimaging analyses result in statistic images of signal-to-noise. However, it is essential to examine both signal and noise individually, to characterize sensitivity and to identify artifacts. Confidence intervals simultaneous convey signal and noise but ...

The two current criteria for diagnosis of left anterior fascicular block (LAFB) were evaluated; they are marked left axis deviation (LAD) and a delay in the time of inscription of the intrinsicoid deflection (ID) in lead aVL asynchronous to V6. From 400 electrocardiograms with a LAD of --30 degrees or greater, 62 percent showed asynchronous activation of the left ventricle. There was only a gen...

Fifty-two human breast tumors were screened for the presence of DNA homology to mouse mammary tumor virus (MMTV) using molecularly cloned MMTV proviral genomic DNA probes and dot-blot hybridization. Seven patients were found to contain an entire provirus (gag, pol, env, and LTR positive at high stringency). Fifty percent (5/10) of patients having a first degree relative with breast carcinoma we...

In 1995, a survey requesting information about the utilization of certain prosthodontic techniques was mailed to 3,544 graduates of a midwestern dental school. Responses were received from 1,455 alumni, representing a 41 percent return rate. In general, the results are consistent with international and national trends and show significant disparity in the utilization rates of certain procedures...

Forty computer.simulated populations were analysed to derive fonnulae for estimating den.5ity of populations from a set of distances from sample points to the nearest member, from that member to its neighbour and from that neighbour to its nearest neighbour. Distances may be truncated or unlimited. The formulae were applied to data from 11 paper.dot and 18 field populations in a total of 37 exp...