An increasing number of studies have demonstrated the important role of microRNAs (miRNAs) in modulating cancer progression and metastasis, but the mechanisms by which miRNAs regulate prostate cancer (PCa) tumorigenesis remain poorly understood. In the present study, we found that miR-340 may act as a tumor suppressor based on our finding that it was significantly downregulated in PCa tumor tis...

A study was conducted to quantify tar formation in a stratified downdraft gasifier using wood pellets. The effect of biomass flow rate on tar concentration was also analyzed, and more than thirty compounds in tar were quantified. Among the different compounds in tar, tertiary condensed products such as toluene, o/p-xylene, naphthalene, phenol, styrene, and indene were observed in significant am...

MicroRNAs (miRNAs/miRs) are 19-25 nucleotide-long, non-coding RNAs that regulate the expression of target genes at the post-transcriptional level. In the present study, the role of miR-340 in breast cancer (BC) was investigated. The overexpression of miR-340 significantly inhibited the proliferation, migration and invasion of human breast MDA-MB-231 cancer cells in vitro. The Rho-associated, co...

For 1,500 years Jewish society had been designed to produce intellectuals. . . . Jewish society was geared to support them. . . . Rich merchants married sages’ daughters; . . . Quite suddenly, around the year 1800, this ancient and highly efficient social machine for the production of intellectuals began to shift its output. Instead of pouring all its products into the closed circuit of rabbini...

BACKGROUND Most neuroendocrine tumors express chromogranin A (CgA). The posttranslational processing of neuroendocrine proteins such as CgA is often specific for the individual tumor. To cope with this variability and improve tumor diagnosis, we developed a processing-independent analysis (PIA) method to measure the total CgA product. METHODS For PIA, samples underwent trypsin treatment follo...

Nitric oxide (*NO) is a pervasive free radical species that concentrates in lipophilic compartments to serve as a potent inhibitor of lipid and low-density lipoprotein oxidation processes. In this study, we synthesized, characterized, and detected nitrated derivatives of linoleic acid (18:2) in human blood plasma using high-pressure liquid chromatography coupled with electrospray ionization tan...

The use of sunscreen products has been advocated by many health care practitioners as a means to reduce skin damage produced by ultraviolet radiation (UVR) from sunlight. There is a need to better understand the efficacy and safety of sunscreen products given this ongoing campaign encouraging their use. The approach used to establish sunscreen efficacy, sun protection factor (SPF), is a useful ...

1.18.1 Beaconing 333 1.18.2 Route-Following 334 1.18.3 Path Integration 335 1.18.4 Map-Based Navigation 336 1.18.4.1 Small-Scale Maps (Centimeters to Meters) 336 1.18.4.2 Large-Scale Maps (Kilometers to Hundreds of Kilometers) 336 1.18.4.3 A Visual-Based Large-Scale Cognitive Map 337 1.18.4.4 A Sun-Calibrated Magnetic Compass 339 1.18.4.5 The Missing Links I – Navigation Behavior 340 1.18.4.5.1...

Abstract: This paper presents the design of terahertz 2× and 4× sub-harmonic down-mixers using Schottky Barrier Diodes fabricated in standard 0.13 μm SiGe BiCMOS technology. The 340 GHz sub-harmonic mixers (SHMs) are designed based on anti-parallel-diode-pairs (APDPs). With the 2nd and 4th harmonic, local oscillator (LO) frequencies of 170 GHz and 85 GHz are used to pump the two 340 GHz SHMs. W...

BACKGROUND Point-of-care (POC) C-reactive protein (CRP) testing is increasingly used in primary care to assist general practitioners (GPs) in the diagnostic workup for various complaints. The present study compares analytical performance, agreement and user-friendliness of five of these POC CRP tests. METHODS The following five POC CRP tests were evaluated: Afinion and NycoCard Reader II (bot...