Gene expression microarrays have been the vanguard of new analytic approaches in high-dimensional biology. Draft sequences of several genomes coupled with new technologies allow study of the influences and responses of entire genomes rather than isolated genes. This has opened a new realm of highly dimensional biology where questions involve multiplicity at unprecedented scales: thousands of ge...

RNA interference (RNAi) is a modality in which small double-stranded RNA molecules (siRNAs) designed to lead to the degradation of specific mRNAs are introduced into cells or organisms. siRNA libraries have been developed in which siRNAs targeting virtually every gene in the human genome are designed, synthesized and are presented for introduction into cells by transfection in a microtiter plat...

A novel hierarchical unbiased group-wise registration is developed to robustly transform each individual image towards a common space for atlas based analysis. This hierarchical group-wise registration approach consists of two main components, (1) data clustering to group similar images together and (2) unbiased group-wise registration to generate a mean image for each cluster. The mean images ...

The GOCE (Gravity eld and steady-state Ocean Circulation Explorer) satellite gravity gradiometry mission maps the Earth’s gravity eld. Harmonic analysis of GOCE observations provides a global gravity eldmodel (GGFM). Three theoretical strategies, namely the direct, the space-wise and the time-wise approach, have been proposed for GOCE harmonic analysis. Based on these threemethods, several GGFM...

The paper describes a solution for the Yandex Personalized Web Search Challenge. The goal of the challenge is to rerank top ten web search query results to bring most personally relevant results on the top, thereby improving the search quality. The paper focuses on feature engineering for learning to rank in web search, including a novel pair-wise feature, shortand long-term personal navigation...

Developing a reliable and intelligent robotic system which enables the remote operation of normally unmanned oil and gas facilities requires innovative and novel technical solutions. Our strategy for meeting these challenges is based on a step-wise approach involving development and validation of the technology in increasingly demanding settings. This starts with proof-of-concept demonstrations...

Regardless the growing popularity of Virtual Reality, the design of Virtual Environments remains a complex task that requires skilled people. To overcome this, we have developed the VR-WISE approach that allows specifying a Virtual Environment at a conceptual level, free from any implementation details, allowing stakeholders not familiar with VR-technology to participate in the design of a VR a...

This review, differential table, and case to test your skills can help you avoid overuse of costly tests and delayed treatment.

We propose a novel classification technique whose aim is to select an appropriate representation for each datapoint, in contrast to the usual approach of selecting a representation encompassing the whole dataset. This datum-wise representation is found by using a sparsity inducing empirical risk, which is a relaxation of the standard L0 regularized risk. The classification problem is modeled as...