wilson disease is a metabolic disorder with an autosomal recessive genetic pattern and occurs in 1-4 of every 100000 individuals. inactivation of the atp7b gene leads to accumulation of the toxic copper to liver and brain causing hepatic and neurological complication. therefore, most patients suffer from chronic hepatic inflammation and central nervous system disorder. nowadays, up to 500 mutat...

A viscosity model, based on Eyring’s absolute rate theory combined with a cubic PR equation of state and Wong-Sandler mixing rule, has been proposed in order to correlate viscosities of aqueous solutions of alkanolamine mixtures at atmospheric pressure and different temperatures. In the proposed method, the energy and size parameters in studied Equation of State (EoS) have been obtained usi...

Ammonia is generally conceded to be the "key intermediate" in biological nitrogen fixation-that is, the compound which reacts to form the first stable organic compound, glutamic acid (Wilson and Burris, 1953). However, there is virtually no information concerning the reactions functioning in the conversion of N2 to ammonia. Reproducible nitrogen fixation by a cell-free preparation from bacteria...

bacground: wilson's disease is a rare autosomal recessive disorder characterized by toxic accumulation of copper in liver and brain. the disorder is caused by mutations in the atp7b gene, encoding a copper transporting p-type atpase. characterization of the spectrum of mutations in this gene is important both for diagnosis and genetic counseling of the families.materials and methods: we en...

Wilson disease is a metabolic disorder with an autosomal recessive genetic pattern and occurs in 1-4 of every 100000 individuals. Inactivation of the ATP7B gene leads to accumulation of the toxic copper to liver and brain causing hepatic and neurological complication. Therefore, most patients suffer from chronic hepatic inflammation and central nervous system disorder. Nowadays, up to ...

Mineral inclusions encapsulated in diamonds are the oldest, deepest, and most pristine samples of Earth's mantle. They provide age and chemical information over a period of 3.5 billion years--a span that includes continental crustal growth, atmospheric evolution, and the initiation of plate tectonics. We compiled isotopic and bulk chemical data of silicate and sulfide inclusions and found that ...

The wing motion during locust flight is caused by alternating contractions of elevator and depressor muscles. These muscle contractions are initiated by bursts of impulses which occur alternately in the elevator and depressor motor neurons (Wilson & Weis-Fogh, 1962) (see Fig. 1). The isolated thoracic ganglia can produce this pattern of impulse bursts in the absence of any patterned input, or e...

BACKGROUND In Wilson disease, copper is not sufficiently excreted into bile due to the absence or malfunction of the Wilson protein copper ATPase in the excretory pathway of hepatocytes. Copper is found in sweat. It is unknown if the Wilson protein plays a role in copper excretion into sweat. It is the aim of this study to investigate Wilson protein expression in sweat glands and analysing its ...