This paper presents and statistically compares eight alternative methods that could possibly be used in the analysis of matched or paired sample data, including situations in which the data being analyzed satisfy the usual assumptions of normality and continuity necessary for the use of parametric tests as well as when the data are numeric and non-numeric measurements on as low as the ordinal s...

The selection of an adequate regression model is the basis for obtaining accurate and reproducible results during the bionalytical method validation. Given the wide concentration range, frequently present in bioanalytical assays, heteroscedasticity of the data may be expected. Several weighted linear and quadratic regression models were evaluated during the selection of the adequate curve fit u...

Methods Patients who underwent LGE CMR between January 2003 and February 2010 <1 month prior to CABG were included. A standard 16 segment model was used for Left ventricular (LV) scar quantification. Patients were categorized into Scar group and No-scar groups. Perfusion time (PT), Cross clamp time (CCT), 30-Day mortality, Ventricular arrhythmia, duration of ventilation, prolonged ICU (ICU-LOS)...

The Wilcoxon-Mann-Whitney statistic is commonly used for a distribution-free comparison of two groups. One requirement for its use is that the sample sizes of the two groups are fixed. This is violated in some of the applications such as medical imaging studies and diagnostic marker studies; in the former, the violation occurs since the number of correctly localized abnormal images is random, w...

OBJECTIVE To evaluate the short-term effects of high-intensity, task-specific vs regular rehabilitation programme on neuromuscular activity and functional changes in elderly inpatients. DESIGN Single-blind, randomized controlled trial. PATIENTS Sixty-two patients, aged 74.1 (standard deviation (SD) 6.9) years, 12.8 (SD 3.6) days after operation of one lower limb. METHODS Allocation to eit...

shaking; (b) Changes in volumetric measurements and image quality due to motion correction). The p-value is shown as calculated with the Wilcoxon rank-sum test when comparing the volumes with and without correction. 1417 Prospective motion correction with FID-triggered image navigators Maryna Babayeva, Pavel Falkovskiy, Tom Hilbert, Guillaume Bonnier, Bénédicte Maréchal, Reto Meuli, Jean-Philip...

Genetic mapping of quantitative trait loci (QTLs) is performed typically by using a parametric approach, based on the assumption that the phenotype follows a normal distribution. Many traits of interest, however, are not normally distributed. In this paper, we present a nonparametric approach to QTL mapping applicable to any phenotypic distribution. The method is based on a statistic ZW, which ...

OBJECTIVES We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF). METHODS We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR...

PURPOSE To evaluate the efficacy and safety of 0.18% sodium hyaluronate ophthalmic solution (Rejena, Vismed) compared with its vehicle for the treatment of signs and symptoms of dry eye disease. DESIGN Randomized, placebo-controlled clinical trial. METHODS A total of 444 subjects with dry eye disease were randomized 1:1 to active study drug (n = 221) or vehicle control (n = 223) in this mul...