A novel and convenient in vitro method for predicting in vivo metabolic clearance in the liver (CL(H)) was developed. The CL(H) of a drug is usually predicted by using both the unbound fraction in serum and the intrinsic hepatic clearance of the unbound fraction, but this procedure is labor-intensive. We simplified the method by directly measuring intrinsic hepatic clearance using isolated rat ...

PRESENTATION Three patients developed acute respiratory failure during treatment of diabetic ketoacidosis (DKA) diagnosed by the combination of hyperglycemia, anion gap metabolic acidosis, and presence of ketone bodies in serum. All three required tracheal intubation and mechanical ventilation. Table 1 shows pertinent laboratory values at admission and immediately before tracheal intubation. Se...

The aim of this study was to determine the effects of dexamethasone (Dex) and α-ketoglutarate (AKG) on the total cholesterol, glucose, Na, Cl, total Ca and K levels, in serum for newborn and neonate piglets. The blood samples were collected from newborn non-suckling piglets born by sows administered from the 91 d of pregnancy to the parturition with AKG and/or Dex (AKG-0.4 g/kg b.w./every day, ...

background: the purpose of this study was to evaluate the levels of zinc (zn), copper (cu), iron (fe) and zinc/ cop­per ratio in the serum of patients with cutaneous leishmaniasis in qom province, center of iran. methods: serum levels of zinc and copper were determined by flame atomic absorption spectrophotometer and serum iron concentration was measured by using an auto analyzer. the study gro...

Macro and micronutrient deficiencies are a significant problem among people in rural areas in developing countries. Deficiencies may lead to an impaired immune system making the organism vulnerable to infections and diseases. In this paper, the dietary intake, anthropometric measurements, zinc and copper levels in serum, of patients with cutaneous leishmaniasis (CL) are compared with a group of...

Platelet-derived growth factor (PDGF), a potent serum mitogen for vascular smooth muscle cells (VSMCs), plays an important role in membrane transport regulation and in atherosclerosis. K-Cl cotransport (K-Cl COT/KCC), the coupled-movement of K and Cl, is involved in ion homeostasis. VSMCs possess K-Cl COT activity and the KCC1 and KCC3 isoforms. Here, we report on the effect of PDGF on K-Cl COT...

the novel bicyclo thieno 1, 2, 3-triazines (btt) namely btt-1, btt-2, btt-3 and btt-4 were evaluated for analgesic anti-inflammatory and antiarthritic activity. analgesic and anti-inflammatory activity was evaluated using hot plate test , formalin induced paw licking test and formalin induced paw edema test respectively, complete fruend’s adjuvant (cfa) induced arthritis model was used for anti...

The inner stripe of the outer medullary collecting tubule is a major distal nephron segment in urinary acidification. To examine the mechanism of basolateral membrane H+/OH-/HCO3- transport in this segment, cell pH was measured microfluorometrically in the inner stripe of the rabbit outer medullary collecting tubule perfused in vitro using the pH-sensitive fluorescent dye, (2',7')-bis(carboxyet...

introduction: stroke is recognized as the third cause of mortality after cardiovascular and cancer diseases, so that lead to death of about 5 million people, annually. there are several scales to early prediction of at risk patients and decreasing the rate of mortality by transferring them to the stroke center. in the present study, the accuracy of cincinnati pre-hospital stroke scale was asses...