نتایج جستجو برای: whether sensory or intellectual
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the exhaustion doctrine refers to one of the limits of intellectual property rights. once a product protected of ip right has been marketed either by the ip right owner or by others whit her consent, the ip right owner cannot prohibit the further commercialization (like the resale) of that product. thus , a critical element in determining that the owner of an ip right has exhausted her/his righ...
The importance of invasion in the complex process of metastasis, although now well established, has been studied with increasing molecular detail due to the development of robust in vitro experimental assays. In this issue of Cancer Research, we highlight a paper published by George Poste and colleagues that compared and contrasted several different invasion assays. The authors concluded that v...
Both referees agree that your results are novel, important and of broad interest. However, both have serious concerns about the strength of the conclusions you are able to draw from your current experiments and ask that you undertake work to improve the evidence presented. Both agree that your final conclusion, that CD95 stimulation activates PLCgamma1 via PDGFR, is not yet well supported by th...
Compelling evidence indicates Type I CD20 immunotherapeutic mAbs promote targeted tumor cell elimination exclusively via immune effector functions, which can be exhausted/saturated. mAb dosing paradigms should therefore take into account the capacity of these cytotoxic mechanisms, leading to the conclusion that lower doses, given frequently, may be far more effective.
Having introduced in the XX century, fast industrialization, emergence of intellectual technologies and leap to mass digitalization have given an impetus global urbanization. In turn, this process has changed city life. order maintain connection stability between human environment, big data, information communication (ICT), sensory innovation technologies, tools based on Internet Things (IoT) p...
Many causal mutations of intellectual disability have been found in genes involved in epigenetic regulations. Replication-independent deposition of the histone H3.3 variant by the HIRA complex is a prominent nucleosome replacement mechanism affecting gene transcription, especially in postmitotic neurons. However, how HIRA-mediated H3.3 deposition is regulated in these cells remains unclear. Her...
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